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VE-Cadherin / CD144 / CDH5 Antibody, Rabbit PAb

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    Rat CDH5 Antibody Product Information
    Immunogen:Recombinant Rat Cadherin-5 / CDH5 / VE-Cad protein (Catalog#80276-R08H)
    Clone ID:
    Ig Type:Rabbit IgG
    Concentration:
    Endotoxin:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    Preparation:Produced in rabbits immunized with purified, recombinant Rat Cadherin-5 / CDH5 / VE-Cad (rR Cadherin-5 / CDH5 / VE-Cad; Catalog#80276-R08H; Met1-Gln585). Total IgG was purified by Protein A affinity chromatography.
    Other CDH5 Antibody Products
    Reactivity: Human  
    Application: ELISA  
      10433-RP01-400
      10433-RP01-200
      10433-RP01-100
      400 µg 
      200 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        10433-T16-50
        10433-T16-200
        10433-T16-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart
        Reactivity: Human  
        Application: FCM  
        • Slide 1
        • Slide 1
        10433-MM01-P-25
        10433-MM01-P-100
        25 Test 
        100 Tests 
        Add to Cart
        Reactivity: Human  
        Application: ELISA  
          10433-MM02-50
          10433-MM02-200
          10433-MM02-100
          50 µg 
          200 µg 
          100 µg 
          Add to Cart
          Reactivity: Human  
          Application: FCM  
          • Slide 1
          • Slide 1
          10433-MM01-F-25
          10433-MM01-F-100
          25 Test 
          100 Tests 
          Add to Cart
          Reactivity: Human  
          Application: FCM  
          • Slide 1
          10433-MM01-50
          10433-MM01-200
          10433-MM01-100
          50 µg 
          200 µg 
          100 µg 
          Add to Cart
          Reactivity: Human  
          Application: ELISA  FCM  
          • Slide 1
          10433-R048-50
          10433-R048-100
          50 µg 
          100 µg 
          Add to Cart
          Reactivity: Human  
          Application: FCM  
          • Slide 1
          10433-MM01-A-25
          10433-MM01-A-100
          25 Test 
          100 Tests 
          Add to Cart
          Reactivity: Human  
          Application: IHC-P  
          • Slide 1
          • Slide 1
          10433-R012-50
          10433-R012-100
          50 µg 
          100 µg 
          Add to Cart
          Reactivity: Mouse  
          Application: ELISA  
            50192-R228-50
            50192-R228-100
            50 µg 
            100 µg 
            Add to Cart
            Reactivity: Mouse  
            Application: FCM  
            • Slide 1
            50192-R201-A-25
            50192-R201-A-100
            25 Test 
            100 Tests 
            Add to Cart
            Reactivity: Mouse  
            Application: ELISA  
              50192-RP02-50
              50192-RP02-200
              50192-RP02-100
              50 µg 
              200 µg 
              100 µg 
              Add to Cart
              Reactivity: Mouse  
              Application: ELISA  
                50192-RP01-400
                50192-RP01-200
                50192-RP01-100
                400 µg 
                200 µg 
                100 µg 
                Add to Cart
                Reactivity: Mouse  
                Application: FCM  
                • Slide 1
                50192-R201-50
                50192-R201-100
                50 µg 
                100 µg 
                Add to Cart
                Reactivity: Mouse  
                Application: ELISA  WB  
                • Slide 1
                50192-R311-50
                50192-R311-100
                50 µg 
                100 µg 
                Add to Cart
                Reactivity: Mouse  
                Application: FCM  
                • Slide 1
                • Slide 1
                50192-R201-P-25
                50192-R201-P-100
                25 Test 
                100 Tests 
                Add to Cart
                Reactivity: Rat  
                Application: ELISA  
                  80276-MM06-50
                  80276-MM06-200
                  80276-MM06-100
                  50 µg 
                  200 µg 
                  100 µg 
                  Add to Cart
                  Reactivity: Rat  
                  Application: WB  
                  • Slide 1
                  80276-MM05-50
                  80276-MM05-200
                  80276-MM05-100
                  50 µg 
                  200 µg 
                  100 µg 
                  Add to Cart
                  Reactivity: Rat  
                  Application: ELISA  
                    80276-T16-50
                    80276-T16-200
                    80276-T16-100
                    50 µg 
                    200 µg 
                    100 µg 
                    Add to Cart
                    VE-Cadherin/CD144 Background

                    Cadherins (Calcium dependent adhesion molecules) are a class of transmembrane proteins. Cadherin-5, also known as VE-cadherin, CDH5 and CD144, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. VE-Cadherin is widely considered to be specific for vascular endothelia in which it is either the sole or the predominant cadherin, often co-existing with N-cadherin. This specificity of VE-cadherin for vascular endothelial cells is important not only in blood and lymph vessel biology and medicine, but also for cell-type-based diagnoses, notably those of metastatic tumors. As a classical cadherin, VE-Cadherin links endothelial cells together by homophilic interactions mediated by its extracellular part and associates intracellularly with the actin cytoskeleton via catenins. Mechanisms that regulate VE-cadherin-mediated adhesion are important for the control of vascular permeability and leukocyte extravasation. In addition to its adhesive functions, VE-Cadherin regulates various cellular processes such as cell proliferation and apoptosis and modulates vascular endothelial growth factor receptor functions. Consequently, VE-cadherin is essential during embryonic angiogenesis.

                    Rat VE-Cadherin/CD144 References
                  • Taveau JC, et al. (2008) Structure of artificial and natural VE-cadherin-based adherens junctions. Biochem Soc Trans. 36(Pt 2): 189-93.
                  • Vestweber D. (2008) VE-cadherin: the major endothelial adhesion molecule controlling cellular junctions and blood vessel formation. Arterioscler Thromb Vasc Biol. 28(2): 223-32.
                  • Gavard J. (2009) Breaking the VE-cadherin bonds. FEBS Lett. 583(1): 1-6.
                  • Vestweber D, et al. (2009) Cell adhesion dynamics at endothelial junctions: VE-cadherin as a major player. Trends Cell Biol. 19(1): 8-15.
                  • Boda-Heggemann J, et al. (2009) Beyond vessels: occurrence and regional clustering of vascular endothelial (VE-)cadherin-containing junctions in non-endothelial cells. Cell Tissue Res. 335(1): 49-65.
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                    Catalog: 80276-RP01-200
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                    Datasheet & Documentation

                    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
                    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"