Cadherin-17 / LI-cadherin Protein & Antibody (CDH17)

Cadherin 17, LI Cadherin (liver-intestine)

Cadherin-17 / LI-cadherin Products

Cadherin-17 / LI-cadherin Protein, Recombinant

Molecule	Species	Description	Cat. No
Cadherin-17/LI-cadherin	Human	Cadherin-17/LI-cadherin Protein, Recombinant	11360-H08H

Cadherin-17 / LI-cadherin Antibody

Molecule	Application	Description	Cat. No
Human Cadherin-17/LI-cadherin	WB, ELISA	Cadherin-17 / LI-cadherin Antibody	11360-MM02
Human Cadherin-17/LI-cadherin	WB, ELISA	Cadherin-17 / LI-cadherin Antibody (Antigen Affinity Purified)	11360-RP02

Cadherin-17 / LI-cadherin cDNA Clone

Molecule	Species	Description	Cat. No
Cadherin-17/LI-cadherin	Human	Homo sapiens Cadherin-17/LI-cadherin/CDH17 cDNA Clone	HG11360-M
Cadherin-17/LI-cadherin	Mouse	Cadherin-17/LI-cadherin/CDH17 cDNA Clone / ORF Clone	MG50942-G
Cadherin-17/LI-cadherin	Rat	CDH17 cDNA Clone / ORF Clone	RG80283-G

Cadherin-17 / LI-cadherin Related Areas

Immunology>>Adhesion Molecule>>Cadherin>>Cadherin-17/LI-cadherin

Cadherin-17 / LI-cadherin Alternative Names

Cadherin-17, LI-cadherin, CDH17, CDH16, FLJ26931, HPT-1, HPT1, MGC138218, MGC142024 [Homo sapiens]

Cadherin-17, LI-cadherin, cdh17, RP23-54P14.2, HPT-1, HPT-1/LI [Mus musculus]

Cadherin-17 / LI-cadherin Related Products

Protein Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
E-Cadherin/CDH1/CD324	Human	E-Cadherin/CDH1 Protein, Recombinant
E-Cadherin/CDH1	Mouse	E-Cadherin/CDH1 Protein, Recombinant
KSP-Cadherin/Cadherin-16/CDH16	Human	KSP-Cadherin/Cadherin-16/CDH16 Protein, Recombinant
N-Cadherin/CD325/CDH2	Human	N-Cadherin/CD325/CDH2 Protein, Recombinant
R-Cadherin/CDH4	Human	R-Cadherin/CDH4 Protein, Recombinant
VE-Cadherin/CD144/CDH5	Human	VE-Cadherin/CD114/Fc Protein, Recombinant
VE-Cadherin/CD144/CDH5	Mouse	VE-Cadherin/CD144/CDH5 Protein, Recombinant
Cadherin-6/K-Cadherin/CDH6	Human	Cadherin-6/K-Cadherin/CDH6 Protein, Recombinant
Cadherin-8/CDH8	Human	Cadherin-8/CDH8 Protein, Recombinant
Cadherin-12/CDH12	Human	Cadherin-12/CDH12 Protein, Recombinant

Antibody Products

Molecule	Applications	Description //For Detailed Info. and Price------CLICK!
Human E-Cadherin/CDH1/CD324	WB, ELISA	Mouse Monoclonal Antibody
Human E-Cadherin/CDH1/CD324	ELISA	Mouse Monoclonal Antibody
Human E-Cadherin/CDH1/CD324	WB, ELISA	Rabbit Polyclonal Antibody
Human E-Cadherin/CDH1/CD324	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)
Human R-Cadherin/CDH4	WB, ELISA	R-Cadherin/CDH4 Antibody, Rabbit PAb
Human R-Cadherin/CDH4	WB, ELISA	R-Cadherin/CDH4 Antibody, Rabbit PAb (Antigen Affinity Purified)
Mouse VE-Cadherin/CD144/CDH5	WB, ELISA	Rabbit Polyclonal Antibody

cDNA Clone Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
E-Cadherin/CDH1/CD324	Human	Homo sapiens E-Cadherin/CDH1 cDNA Clone(NM_004360.3)
KSP-Cadherin/Cadherin-16/CDH16	Human	Homo sapiens KSP-Cadherin/Cadherin-16/CDH16 cDNA Clone
N-Cadherin/CD325/CDH2	Human	Homo sapiens N-Cadherin/CD325/CDH2 cDNA Clone(NM_001792.3)
P-Cadherin/CDH3	Human	Homo sapiens P-Cadherin/CDH3 cDNA Clone(NM_001793.4)
VE-Cadherin/CD144/CDH5	Human	Homo sapiens VE-Cadherin/CD144/CDH5 cDNA Clone(NM_001795.3)
VE-Cadherin/CD144/CDH5	Mouse	Mus musculus VE-Cadherin/CD114/CDH5 cDNA Clone
Cadherin-6/K-Cadherin/CDH6	Human	Homo sapiens Cadherin-6/K-Cadherin/CDH6 cDNA Clone(NM_004932.2)
Cadherin-8/CDH8	Human	Homo sapiens Cadherin-8/CDH8 cDNA Clone(NM_001796.2)
Cadherin-11/CDH11	Human	Homo sapiens Cadherin-11/CDH11 cDNA Clone(NM_001797.2)
Cadherin-12/CDH12	Human	Homo sapiens Cadherin-12/CDH12 cDNA Clone(NM_004061.3)

Cadherin-17 / LI-cadherin Background

Cadherin-17 or LI-cadherin is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Cadherin-17/LI-cadherin is a cadherin-like protein consisting of an extracellular region, 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing of the encoding gene results in multiple transcript variants. Cadherin-17/LI-cadherin preferentially interact with themselves in a homophilic manner in connecting cells. Cadherin-17 may thus contribute to the sorting of heterogeneous cell types and have a role in the morphological organization of liver and intestine. It's also involved in intestinal peptide transport. Experiments have reported the association between Cadherin-17/LI-cadherin and gastric cancer. Cadherin-17/LI-cadherin expression was detected in 63/94 of gastric adenocarcinomas in addition to intestinal metaplasia. The expression of Cadherin-17 tended to be associated with intestinal type carcinoma, and carcinomas with Cadherin-17 expression was significantly more frequent in advanced stage cases than in early stage. Cadherin-17 is also a useful immunohistochemical marker for diagnosis of adenocarcinomas of the digestive system.

Cadherin-17 / LI-cadherin Related Studies

1. Liu LX, et al. (2009) Targeting cadherin-17 inactivates Wnt signaling and inhibits tumor growth in liver carcinoma. Hepatology. 50(5): 1453-63.
2. Ito R, et al. (2005) Clinicopathological significant and prognostic influence of cadherin-17 expression in gastric cancer. Virchows Arch. 447(4): 717-22.
3. Horsfield J, et al. (2002) Cadherin-17 is required to maintain pronephric duct integrity during zebrafish development. Mech Dev. 115(1-2): 15-26.