Anti-CDH17 Antibody

Cat: 11360-MM02
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Anti-CDH17 Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-CDH17 Antibody
Validated applications
Species reactivity
Reacts with: Human
Human CDH17
No cross-reactivity in ELISA with Human Cadherin-5 Human Cadherin-8 Human E-Cadherin Human cell lysate (293 cell line)
Recombinant Human CDH17 / Cadherin-17 Protein (Catalog#11360-H08H)
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CDH17 / Cadherin-17 (rh CDH17 / Cadherin-17; Catalog #11360-H08H; Met 1-Met 787; Q12864-1). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Monoclonal Mouse IgG2a Clone #4F6H5
Protein A
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CDH17 Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CDH17 Antibody Alternative Names
Anti-CDH16 Antibody;Anti-HPT-1 Antibody;Anti-HPT1 Antibody
CDH17 Background Information

Cadherin-17 or LI-cadherin is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Cadherin-17/LI-cadherin is a cadherin-like protein consisting of an extracellular region, 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing of the encoding gene results in multiple transcript variants. Cadherin-17/LI-cadherin preferentially interact with themselves in a homophilic manner in connecting cells. Cadherin-17 may thus contribute to the sorting of heterogeneous cell types and have a role in the morphological organization of liver and intestine. It's also involved in intestinal peptide transport. Experiments have reported the association between Cadherin-17/LI-cadherin and gastric cancer. Cadherin-17/LI-cadherin expression was detected in 63/94 of gastric adenocarcinomas in addition to intestinal metaplasia. The expression of Cadherin-17 tended to be associated with intestinal type carcinoma, and carcinomas with Cadherin-17 expression was significantly more frequent in advanced stage cases than in early stage. Cadherin-17 is also a useful immunohistochemical marker for diagnosis of adenocarcinomas of the digestive system.

Full Name
cadherin 17, LI cadherin (liver-intestine)
  • Liu LX, et al. (2009) Targeting cadherin-17 inactivates Wnt signaling and inhibits tumor growth in liver carcinoma. Hepatology. 50(5): 1453-63.
  • Ito R, et al. (2005) Clinicopathological significant and prognostic influence of cadherin-17 expression in gastric cancer. Virchows Arch. 447(4): 717-22.
  • Horsfield J, et al. (2002) Cadherin-17 is required to maintain pronephric duct integrity during zebrafish development. Mech Dev. 115(1-2): 15-26.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CDH17 Antibody Rabbit Polyclonal ELISA 80283-T16
    Anti-CDH17 Antibody Rabbit Polyclonal IHC-P 107971-T08
    Anti-CDH17 Antibody Mouse Monoclonal IHC-P 11360-MM05
    Anti-CDH17 Antibody Rabbit Polyclonal ELISA 11360-RP01
    Anti-CDH17 Antibody Rabbit Monoclonal IHC-P 11360-R029
    Anti-CDH17 Antibody Rabbit Monoclonal ELISA 11360-R032
    Anti-CDH17 Antibody Rabbit Polyclonal WB,ELISA,IHC-P,IP 11360-RP02
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