Quick Order

Cadherin-12 / CDH12 Antibody (FITC), Mouse MAb

DatasheetReviewsRelated ProductsProtocols
Human CDH12 Antibody Product Information
Immunogen:Recombinant Human Cadherin-12 / CDH12 protein (Catalog#10317-H08H)
Clone ID:01
Ig Type:Mouse IgG1
Concentration:10 μl/Test, 0.1 mg/ml
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Cadherin-12 / CDH12 (rh Cadherin-12 / CDH12; Catalog#10317-H08H; NP_001783.2; Met 1-Ala 605) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Human CDH12 Antibody FC Application Image
AFP / alpha-fetoprotein Antibody, Mouse MAb, Flow cytometric
[Click to enlarge image]
Caption:
Flow cytometric analysis of Human AFP expression in HepG2 cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), and stained with Purified Mouse anti-AFP (12177-MM24, 1 μg/test), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Cadherin-12 / CDH12 Antibody (FITC), Mouse MAb, Flow cytometric
[Click to enlarge image]
Caption:
Flow cytometric analysis of anti-human CDH12 on Jurkat cells.
Other CDH12 Antibody Products
Reactivity: Human  
Application: ELISA  
    10317-R403-50
    10317-R403-100
    50 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  
      10317-T16-50
      10317-T16-200
      10317-T16-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        10317-MM01-50
        10317-MM01-200
        10317-MM01-100
        50 µg 
        200 µg 
        100 µg 
        Add to Cart
        Reactivity: Human  
        Application: FCM  
        • Slide 1
        10317-MM01-P-25
        10317-MM01-P-100
        25 Test 
        100 Tests 
        Add to Cart
        Reactivity: Human  
        Application: ELISA  
          10317-RP01-400
          10317-RP01-200
          10317-RP01-100
          400 µg 
          200 µg 
          100 µg 
          Add to Cart
          Cadherin-12/CDH12 Background

          Classic Cadherins represent a family of calcium-dependent homophilic cell-cell adhesion molecules. They confer strong adhesiveness to animal cells when they are anchored to the actin cytoskeleton via their cytoplasmic binding partners, catenins. The cadherin/catenin adhesion system plays key roles in the morphogenesis and function of the vertebrate and invertebrate nervous systems. Furthermore, this system is involved in synaptic plasticity. Recent studies on the role of individual cadherin subtypes at synapses indicate that individual cadherin subtypes play their own unique role to regulate synaptic activities. Type II (atypical) cadherins are defined based on their lack of an HAV cell adhesion recognition sequence specific to type I cadherins. It has been observed that cells containing a specific cadherin subtype tend to cluster together to the exclusion of other types, both in cell culture and during development. Cadherin-12 also known as CDH12, is a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Cadherin-12 appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.

          Human Cadherin-12/CDH12 References
        • Tanihara H, et al. (1994) Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin. Cell Adhes Commun. 2(1): 15-26.
        • Suzuki SC, et al. (2008) Cadherins in neuronal morphogenesis and function. Dev Growth Differ. 50 Suppl 1: S119-30.
        • Product nameProduct name