Anti-CDH12 Antibody (FITC)

Cat: 10317-MM01-F

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Anti-CDH12 Antibody (FITC) (Mouse Monoclonal antibody) General Information
Product name
Anti-CDH12 Antibody (FITC)
Validated applications
Species reactivity
Reacts with: Human
Human CDH12
Recombinant Human Cadherin-12 / CDH12 protein (Catalog#10317-H08H)
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Cadherin-12 / CDH12 (rh Cadherin-12 / CDH12; Catalog#10317-H08H; NP_001783.2; Met 1-Ala 605) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Monoclonal Mouse IgG1 Clone #01
Protein A
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
10 μl/Test, 0.1 mg/ml
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Anti-CDH12 Antibody (FITC) (Mouse Monoclonal antibody) Validated Applications

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CDH12 Antibody (FITC) (Mouse Monoclonal antibody) Images
Human Cadherin-12/CDH12 Flow Cytometry (FC) 5355
Flow cytometric analysis of Human AFP expression in HepG2 cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), and stained with Purified Mouse anti-AFP (12177-MM24, 1 μg/test), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Human Cadherin-12/CDH12 Flow Cytometry (FC) 5410
Flow cytometric analysis of anti-human CDH12 on Jurkat cells.
Anti-CDH12 Antibody (FITC) Alternative Names
Anti-CDHB Antibody
CDH12 Background Information

Classic Cadherins represent a family of calcium-dependent homophilic cell-cell adhesion molecules. They confer strong adhesiveness to animal cells when they are anchored to the actin cytoskeleton via their cytoplasmic binding partners, catenins. The cadherin/catenin adhesion system plays key roles in the morphogenesis and function of the vertebrate and invertebrate nervous systems. Furthermore, this system is involved in synaptic plasticity. Recent studies on the role of individual cadherin subtypes at synapses indicate that individual cadherin subtypes play their own unique role to regulate synaptic activities. Type II (atypical) cadherins are defined based on their lack of an HAV cell adhesion recognition sequence specific to type I cadherins. It has been observed that cells containing a specific cadherin subtype tend to cluster together to the exclusion of other types, both in cell culture and during development. Cadherin-12 also known as CDH12, is a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Cadherin-12 appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.

Full Name
cadherin 12, type 2 (N-cadherin 2)
  • Tanihara H, et al. (1994) Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin. Cell Adhes Commun. 2(1): 15-26.
  • Suzuki SC, et al. (2008) Cadherins in neuronal morphogenesis and function. Dev Growth Differ. 50 Suppl 1: S119-30.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CDH12 Antibody (PE) Mouse Monoclonal FCM 10317-MM01-P
    Anti-CDH12 Antibody Rabbit Polyclonal ELISA 10317-T16
    Anti-CDH12 Antibody Mouse Monoclonal ELISA 10317-MM01
    Anti-CDH12 Antibody Rabbit Monoclonal ELISA 10317-R403
    Anti-CDH12 Antibody Rabbit Polyclonal ELISA 10317-RP01
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