Anti-CDH12 Antibody

Cat: 10317-MM01
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Anti-CDH12 Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-CDH12 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human CDH12
No cross-reactivity in ELISA with Human Cadherin-4 Human Cadherin-6 Human Cadherin-8 Human E-Cadherin Human cell lysate (293 cell line)
Immunogen
Recombinant Human Cadherin-12 / CDH12 Protein (Catalog#10317-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Cadherin-12 / CDH12 (rh Cadherin-12 / CDH12; Catalog #10317-H08H; NP_001783.2; Met 1-Ala 605). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG1 Clone #01
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CDH12 Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CDH12 Antibody Alternative Names
Anti-CDHB Antibody
CDH12 Background Information

Classic Cadherins represent a family of calcium-dependent homophilic cell-cell adhesion molecules. They confer strong adhesiveness to animal cells when they are anchored to the actin cytoskeleton via their cytoplasmic binding partners, catenins. The cadherin/catenin adhesion system plays key roles in the morphogenesis and function of the vertebrate and invertebrate nervous systems. Furthermore, this system is involved in synaptic plasticity. Recent studies on the role of individual cadherin subtypes at synapses indicate that individual cadherin subtypes play their own unique role to regulate synaptic activities. Type II (atypical) cadherins are defined based on their lack of an HAV cell adhesion recognition sequence specific to type I cadherins. It has been observed that cells containing a specific cadherin subtype tend to cluster together to the exclusion of other types, both in cell culture and during development. Cadherin-12 also known as CDH12, is a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Cadherin-12 appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.

Full Name
cadherin 12, type 2 (N-cadherin 2)
References
  • Tanihara H, et al. (1994) Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin. Cell Adhes Commun. 2(1): 15-26.
  • Suzuki SC, et al. (2008) Cadherins in neuronal morphogenesis and function. Dev Growth Differ. 50 Suppl 1: S119-30.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CDH12 Antibody (PE) Mouse Monoclonal FCM 10317-MM01-P
    Anti-CDH12 Antibody (FITC) Mouse Monoclonal FCM 10317-MM01-F
    Anti-CDH12 Antibody Rabbit Monoclonal ELISA 10317-R403
    Anti-CDH12 Antibody Rabbit Polyclonal ELISA 10317-RP01
    Anti-CDH12 Antibody Rabbit Polyclonal ELISA 10317-T16
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