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Cynomolgus monkey CXCL9 Gene cDNA Clone (full-length ORF Clone)

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CXCL9cDNA Clone Product Information
Gene Bank Ref.ID:unsubmitted
cDNA Size:378
cDNA Description:ORF Clone of Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) chemokine (C-X-C motif) ligand 9 DNA.
Gene Synonym:CXCL9
Species:Cynomolgus
Vector:pGEM-T Vector
Restriction Site:
Tag Sequence:
Sequence Description:Identical with XM_001091286.2 [ Macaca mulatta (Rhesus monkey) ] sequence. Please check the sequence information before order.
Shipping Carrier:Each tube contains approximately 10 μg of lyophilized plasmid.
Storage:The lyophilized plasmid can be stored at ambient temperature for three months.
pGEM-T Vector Information

The pGEM-T is 3kb in length, and contains the amplicin resistance gene, conferring selection of the plasmid in E. coli, and the ori site which is the bacterial origin of replication. The plasmid has multiple cloning sites as shown below. The coding sequence was inserted by TA cloning. Many E. coli strains are suitable for the propagation of this vector including JM109, DH5α and TOP10.

pGEM-T Simple Usage Suggestion:

The coding sequence can be easily obtained by digesting the vector with proper restriction enzyme(s). The coding sequence can also be amplified by PCR with M13 primers, or primer pair SP6 and T7.

Vector Sequence Download
Cynomolgus monkey CXCL9 Gene cDNA Clone (full-length ORF Clone) on other vectors
Chemokine & Receptor Related Products
Product nameProduct name
Mouse MCP-3 / CCL7 Protein (His Tag)Human CCL5 / RANTES ProteinMouse CXCL14 / BRAK ProteinMouse CXCL12 / SDF-1 ProteinMouse CCL6 / C-C motif ligand 6 Protein (His Tag)Mouse CXCL1 / MGSA / NAP-3 ProteinHuman CCL22 / MDC Protein (His Tag)Human CCL8 / MCP-2 Protein (SUMO Tag)Mouse CCL17 / TARC ProteinMouse CCL20 / MIP-3 alpha Protein (His Tag)Canine CXCL12 / SDF-1 ProteinCanine CXCL13 / BCA-1 Protein (His Tag)Canine CXCL16 / SR-PSOX Protein (Fc Tag)Canine CXCL16 / SR-PSOX Protein (His Tag)Canine Fractalkine / CX3CL1 Protein (Fc Tag)Canine Fractalkine / CX3CL1 ProteinCanine XCL1 Protein (His Tag)Human CCL13 / MCP-4 Protein (His Tag)Human IL-8 / CXCL8 ProteinHuman CCL18 / PARC / MIP4 Protein (His Tag)Rat CCL3 / Mip1a ProteinMouse CXCL9 / MIG / C-X-C motif chemokine 9 ProteinHuman CCL4 / MIP1B Protein (His Tag)Human CCL3 / Mip1a Protein (His Tag)Mouse CXCL2 / GRO2 / MIP-2 (His & SUMO Tag)Human CXCL3 / GRO gamma Protein (His Tag)Rat NAP-2 / PPBP / CXCL7 Protein (Fc Tag)Human CXCL4 / PF4 ProteinRat CXCL16 / SR-PSOX Protein (Fc Tag)Rat CXCL16 / SR-PSOX Protein (His Tag)Mouse CCL2 / MCP-1 / MCP1 Protein (His Tag)Human CXCL9 / MIG / C-X-C motif chemokine 9 ProteinHuman CCL2 / MCP-1 / MCP1 Protein (His Tag)Human CCL27 / CTACK Protein (His Tag)Human CCL16 / HCC-4 / NCC4 Protein (His Tag)Human CCL17 / TARC / SCYA17 Protein (His Tag)Human CCL17 / TARC / SCYA17 ProteinHuman Fractalkine / CX3CL1 Protein (His Tag)Human CCL23 / MIP 3 Protein (His Tag)Human CCL16 / HCC-4 / NCC4 Protein (His Tag)Human CCL23 / MIP 3 ProteinMouse XCL1 Protein (His Tag)Human NAP-2 / PPBP / CXCL7 Protein (His Tag)Human XCL1 Protein (His Tag)Mouse CXCL16 / SR-PSOX Protein (His Tag)Cynomolgus CXCL12 / SDF-1 Protein (Fc Tag)Human CCL28 Protein (His Tag)Mouse I-309 / CCL1 / TCA-3 Protein (Fc Tag)Cynomolgus CXCL13 / BCA-1 / BLC Protein (His Tag)Mouse CCL8 / MCP-2 Protein (His & NusA Tag)Mouse NAP-2 / PPBP / CXCL7 Protein (aa 49-109, His Tag)Mouse NAP-2 / PPBP / CXCL7 Protein (aa 40-113, His Tag)Cynomolgus CCL17 / TARC Protein (His Tag)Cynomolgus XCL1 Protein (His Tag)Cynomolgus NAP-2 / PPBP / CXCL7 Protein (Fc Tag)Cynomolgus CXCL9 / MIG / C-X-C motif chemokine 9 ProteinCynomolgus CCL21 / 6Ckine ProteinCynomolgus / Rhesus Fractalkine / CX3CL1 Protein (Fc Tag)Human CXCL1 / MGSA / NAP-3 ProteinHuman XCL2 Protein (His Tag)Human CXCL12 / SDF-1 Protein (isoform a, His Tag)Human CXCL12 / SDF-1 Protein (isoform a)Human CXCL10 / Crg-2 ProteinCynomolgus IL-8 / CXCL8 ProteinHuman FAM19A4 / TAFA4 Protein (Fc Tag)Human FAM19A2 Protein (Fc Tag)Human CXCL2 / MIP-2 ProteinRat CXCL1 / MGSA / NAP-3 ProteinRat CXCL2 / MIP-2 ProteinHuman MCP-3 / CCL7 Protein (His Tag)Human MCP-3 / CCL7 Protein (His Tag)Mouse CCL3 / Mip1a ProteinHuman I-309 / CCL1 / TCA-3 Protein (Fc Tag)Human I-309 / CCL1 / TCA-3 ProteinHuman CXCL1 / MGSA / NAP-3 Protein (His & NusA Tag)Canine IL-8 / CXCL8 ProteinHuman CXCL1 / MGSA / NAP-3 Protein (His & SUMO Tag)Human CXCL14 / BRAK ProteinHuman CXCL5 ProteinHuman CCL15 / MIP-5 / MIP-1 delta Protein (aa 22-113, His Tag)Human CCL15 / MIP-5 / MIP-1 delta Protein (aa 46-113, His Tag)Human CCL5 / RANTES Protein (His & mucin Tag)Human CCL24 / Eotaxin-2 / MPIF-2 Protein (His Tag)Human IL-8 / CXCL8 Protein (aa 1-77, Fc Tag)Human IL-8 / CXCL8 Protein (aa 6-77, Fc Tag)Human IL-8 / CXCL8 Protein (aa 1-77)Human IL-8 / CXCL8 Protein (aa 6-77)Human CCL21 / 6Ckine ProteinHuman CCL11 Protein (His Tag)Human CCL14 / HCC-1 / HCC-3 Protein (His Tag)Human CCL14 / HCC-1 / HCC-3 Protein (aa 28-93, His Tag)Human CXCL12 / SDF1b Protein (Fc Tag)Human CXCL12 / SDF-1 ProteinHuman CCL20 / MIP-3 alpha Protein (His Tag)
Background

Chemokine (C-X-C motif) ligand 9 (CXCL9), also known as Monokine induced by gamma interferon (MIG), is a small cytokine belonging to the CXC chemokine family. The function of this chemokine has not been specifically defined; however, it is thought to be involved in T cell trafficking. CXCL9/MIG functions as one of the three ligands of chemokine receptor CXCR3 which is a G protein-coupled receptor found predominantly on T cells. CXCL9/MIG, together with CXCL10 and CXCL11, may activate CXCR3 by binding to it. CXCL9 serves as a cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. It has been observed that tumour endothelial cells secrete high levels of CXCL9 in all, and CXCL10 in most melanoma metastases. Experiment data represent novel mechanisms by which tumour cells in melanoma metastases might use the chemokine-expressing endothelium to leave the tumour and eventually to form additional metastases at distinct sites. Experiment results also improved that CXCL9/MIG plays an important role in CD4+ T lymphocyte recruitment and development of CAV, MOMA-2+ macrophages are the predominant recipient-derived source of CXCL9/MIG, and recipient CD4 lymphocytes are necessary for sustained CXCL9/MIG production and CAV development in this model. Neutralization of the chemokine CXCL9/MIG may have therapeutic potential for the treatment of chronic rejection after heart transplantation.

References
  • Ruehlmann JM, et al. (2001) MIG (CXCL9) chemokine gene therapy combines with antibody-cytokine fusion protein to suppress growth and dissemination of murine colon carcinoma. Cancer Res. 61(23): 8498-503.
  • Belperio JA, et al. (2003) Role of CXCL9/CXCR3 chemokine biology during pathogenesis of acute lung allograft rejection. J Immunol. 171(9): 4844-52.
  • Colvin RA, et al. (2004) Intracellular domains of CXCR3 that mediate CXCL9, CXCL10, and CXCL11 function. J Biol Chem. 279(29): 30219-27.
  • Valbuena G, et al. (2003) Expression analysis of the T-cell-targeting chemokines CXCL9 and CXCL10 in mice and humans with endothelial infections caused by rickettsiae of the spotted fever group. Am J Pathol. 163(4): 1357-69.
  • Catalog:CG90135-G
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