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Product Catalog
> CXCL4 / PF4 Protein & Antibody CXCL4 / PF4 Protein & Antibody
Chemokine (C-X-C motif) Ligand 4 / Platelet Factor 4
CXCL4 / PF4 Products
CXCL4 / PF4 Protein, Recombinant
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| CXCL4/PF4 | Human | CXCL4/PF4 Protein, Recombinant |
10874-HNAE |
CCXCL4 / PF4 Antibody
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Human CXCL4/PF4 | WB, ELISA | Rabbit Polyclonal Antibody | 10874-RP01 |
CCXCL4 / PF4 cDNA Clone
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| CXCL4/PF4 | Human | Homo sapiens CXCL4/PF4 cDNA Clone(NM_002619.2) | HG10874-M |
| CXCL4/PF4 | Mouse | Mus musculus CXCL4/PF4 cDNA Clone | MG50144-M |
CXCL4 / PF4 Related Areas
Cardiovascular>>Platelet>>CXCL4/PF4
Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>CXCL4/PF4
Immunology>>Cytokine & Receptor>>Chemokine & Receptor>>CXCL4/PF4
CXCL4 / PF4 Alternative Names
CXCL4, PF4, SCYB4, MGC138298 [Homo sapiens]
Cxcl4, Pf4, Scyb4 [Mus musculus]
CXCL4 / PF4 Background
Platelet factor 4 (PF4), also known as chemokine (C-X-C motif) ligand 4 (CXCL4), is a small cytokine belonging to the CXC chemokine family. CXCL4/PF4 is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, CXCL4/PF4 probably has a role in inflammation and wound repair. This protein is released during platelet aggregation. CXCL4/PF4 neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. CXCL4 is chemotactic for neutrophils and monocytes. It inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form. CXCL4/PF4 is up-regulated in human liver fibrosis and that it plays a nonredundant, functional role in experimental liver fibrosis by mediating stellate cell proliferation, migration, and intrahepatic immune cell recruitment.
CXCL4 / PF4 Related Studies
- Zaldivar MM, et al. (2010) CXC chemokine ligand 4 (Cxcl4) is a platelet-derived mediator of experimental liver fibrosis. Hepatology. 51(4): 1345-53.
- Lasagni L, et al. (2007) PF-4/CXCL4 and CXCL4L1 exhibit distinct subcellular localization and a differentially regulated mechanism of secretion. Blood. 109(10): 4127-34.
- Struyf S, et al. (2004) Platelets release CXCL4L1, a nonallelic variant of the chemokine platelet factor-4/CXCL4 and potent inhibitor of angiogenesis. Circ Res. 95(9): 855-7.
