CXCL2 / MIP-2 Protein

Chemokine (C-X-C motif) Ligand 2 / Macrophage Inflammatory Protein 2

CXCL2 / MIP-2 Products

CXCL2 / MIP-2 Protein, Recombinant

Molecule	Species	Description	Cat. No
CXCL2/MIP-2	Mouse	CXCL2/MIP-2 Protein, Recombinant, with SUMO Tag	50070-M28E

CXCL2 / MIP-2 cDNA Clone

Molecule	Species	Description	Cat. No
CXCL2/MIP-2	Human	Human CXCL2/MIP-2 cDNA Clone / ORF Clone	HG10586-M
CXCL2/MIP-2	Mouse	Mouse CXCL2/MIP-2 cDNA Clone / ORF Clone	MG50070-M
CXCL2/MIP-2	Rat	Rat CXCL2/MIP-2 cDNA Clone / ORF Clone	RG80042-M

CXCL2 / MIP-2 Related Areas

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>CXCL2/MIP-2

Immunology>>Cytokine & Receptor>>Chemokine & Receptor>>CXCL2/MIP-2

CXCL2 / MIP-2 Alternative Names

CXCL2, MIP-2, CINC-2a, GRO2, GROb, MGSA-b, MIP-2a, MIP2, MIP2A, SCYB2 [Homo sapiens]

Cxcl2, MIP-2, CINC-2a, GROb, Gro2, MIP-2a, Mgsa-b, Mip2, Scyb, Scyb2 [Mus musculus]

CXCL2 / MIP-2 Background

Chemokine (C-X-C motif) ligand 2 (CXCL2), also called macrophage inflammatory protein 2 (MIP-2), Growth-regulated protein beta (Gro-beta) and Gro oncogene-2 (Gro-2), is a small cytokine belonging to the CXC chemokine family. CXCL2/MIP-2 is selectively up-regulated in tolerance-conferring APCs and serves to recruit NKT cells to the splenic marginal zone, where they form clusters with APCs and T cells. In the absence of the high-affinity receptor for CXCL2/MIP-2 or in the presence of a blocking Ab to CXCL2/MIP-2, peripheral tolerance is prevented, and Ag-specific T regulatory cells are not generated. CXCL2/MIP-2 is selectively up-regulated in tolerance-conferring APCs and serves to recruit NKT cells to the splenic marginal zone, where they form clusters with APCs and T cells. In the absence of the high-affinity receptor for MIP-2 (as in CXCR2-deficient mice) or in the presence of a blocking Ab to MIP-2, peripheral tolerance is prevented, and Ag-specific T regulatory cells are not generated. Understanding the regulation of lymphocyte traffic during tolerance induction may lead to novel therapies for autoimmunity, graft acceptance, and tumor rejection. Several studies have implicated the CXCL2 chemokine as a mediator in the development of sepsis. CXCL2/MIP-2 also plays a major role in mediating the neutrophilic inflammatory response of the rodent lung to particles such as quartz, crocidolite asbestos, as well as high doses of other relative innocuous dusts such as titanium dioxide.

CXCL2 / MIP-2 Related Studies

1. Driscoll KE. (2000) TNFalpha and MIP-2: role in particle-induced inflammation and regulation by oxidative stress. Toxicol Lett. 112-113: 177-83.
2. Walpen S, et al. (2001) Nitric oxide induces MIP-2 transcription in rat renal mesangial cells and in a rat model of glomerulonephritis. FASEB J. 15(3): 571-3.
3. Fahey TJ, et al. (1990) Cytokine production in a model of wound healing: the appearance of MIP-1, MIP-2, cachectin/TNF and IL-1. Cytokine. 2(2): 92-9.