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CXCL16 Protein (SR-PSOX Protein)

Chemokine (C-X-C motif) Ligand 16 (Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein)

CXCL16 Products

CXCL16 Protein, Recombinant

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
CXCL16 Mouse CXCL16/SR-PSOX Protein, Recombinant 50142-M08H
CXCL16 Rat CXCL16 / SRPSOX Protein, Recombinant 80149-R02H
CXCL16 Rat CXCL16/SR-PSOX Protein, Recombinant 80149-R08H

CXCL16 cDNA Clone

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
CXCL16/SR-PSOX Human Homo sapiens CXCL16/SR-PSOX cDNA Clone(NM_001100812.1) HG10834-M
CXCL16/SR-PSOX Mouse Mus musculus CXCL16/SR-PSOX cDNA Clone MG50142-M
CXCL16/SR-PSOX Canine Canine CXCL16 Gene cDNA Clone / ORF Clone DG70060-G
CXCL16/SR-PSOX Rat Rat CXCL16/SR-PSOX cDNA Clone RG80149-G

CXCL16 Alternative Names

CXCL16, SR-PSOX, SRPSOX, CXCLG16 [Homo sapiens]

CXCL16, SR-PSOX, Zmynd15, DN-491F10.6, 0910001K24Rik, AV290116, BB024863 [Mus musculus]

CXCL16 Related Areas

Immunology>>Cytokine & Receptor>>Chemokine & Receptor>>CXCL16/SR-PSOX

CXCL16 Background

C-X-C motif chemokine 16, also known as Small-inducible cytokine B16, SR-PSOX, and CXCL16, is a single-pass type I membrane protein which belongs to the intercrine alpha (chemokine CxC) family. CXCL16 exists in transmembrane and soluble forms. The transmembrane form acts as a scavenger receptor for oxidised LDL whereas the soluble form acts a chemoattractant for mainly CD8+ T cells. CXCL16 is a protein which shares pattern recognition receptor functions, relevant for adhesion and phagocytosis of bacterial products, with the properties of an adhesion molecule and inflammatory chemokine. CXCL16/SR-PSOX is an interferon-gamma-regulated chemokine and scavenger receptor for oxidized low-density lipoprotein that is expressed in atherosclerotic lesions. Proteolytic cleavage of membrane-bound CXCL16 releases soluble CXCL16, which may promote migration of effector T cells and augment a proatherogenic inflammatory response. CXCL16/SR-PSOX can be a potential player in atherogenesis. Enhanced expression of CXCL16 has been demonstrated in atherosclerotic plaques and several properties have been attributed to CXCL16 that could influence the atherosclerotic process. Following in vitro studies suggested that as an adhesion molecule CXCL16/SR-PSOX might mediate T-cell adhesion to the endothelium, as a chemokine-drive T-cell migration, stimulate cell proliferation and elicit inflammatory phenotype in smooth muscle cells (SMC) and, finally, as a scavenger receptor-mediate uptake of atherogenic lipoproteins by macrophages and SMC. CXCR6 and its ligand CXCL16 in regulating metastasis and invasion of cancer. CXCR6 and CXCL16 are up-regulated in multiple cancer tissue types and cancer cell lines relative to normal tissues and cell lines. In addition, both CXCR6 and CXCL16 levels increase as tumor malignancy increases. Thus, CXCL16 and CXCR6 may mark cancers arising in an inflammatory milieu and mediate pro-tumorigenic effects of inflammation through direct effects on cancer cell growth and by inducing the migration and proliferation of tumor-associated leukocytes.

CXCL16 Related Studies

  1. Sheikine Y, et al. (2008) CXCL16/SR-PSOX--a friend or a foe in atherosclerosis? Atherosclerosis. 197(2): 487-95.
  2. Lehrke M, et al. (2008) CXCL16 is a surrogate marker of inflammatory bowel disease. Scand J Gastroenterol. 43(3): 283-8.
  3. Jansson AM, et al. (2009) Soluble CXCL16 predicts long-term mortality in acute coronary syndromes. Circulation. 119(25): 3181-8.
  4. Darash-Yahana M, et al. (2009) The chemokine CXCL16 and its receptor, CXCR6, as markers and promoters of inflammation-associated cancers. PLoS One. 4(8): e6695.
  5. Deng L, et al. (2010) CXCR6/CXCL16 functions as a regulator in metastasis and progression of cancer. Biochim Biophys Acta. 1806(1): 42-9.



CXCL16/SR-PSOX related areas, pathways, and other information