CXCL12 / SDF-1 Protein Price Inquiry ( Available Sizes )
CXCL12 / SDF-1 Protein Product Information
||CXCL12，PBSF, SCYB12, SDF-1a, SDF-1b, SDF1, SDF1A, SDF1B, TLSF-a, TLSF-b, TPAR1
A DNA sequence encoding the human CXCL12 isoform alpha (P48061-2) (Lys 22-Lys 89) was expressed, with a polyhistidine tag at the N-terminus.
CXCL12 / SDF-1 Protein QC Testing
||> 90 % as determined by SDS-PAGE
CXCL12 / SDF-1 protein
||Please contact us for more information.
||Samples are stable for up to twelve months from date of receipt at -70℃
|Predicted N terminal:
The recombinant human CXCL12 consists of 84 amino acids and predicts a molecular mass of 10 KDa. It migrates as an approximately 12KDa band in SDS-PAGE under reducing conditions.
||Lyophilized from sterile PBS，pH 7.4.
- Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
- Please contact us for any concerns or special requirements.
CXCL12 / SDF-1 Protein Usage Guide
||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
CXCL12 / SDF-1 Protein Related Products & Topics
CXCL12 / SDF-1 Protein Description
Stromal cell-derived factor 1, also known as C-X-C motif chemokine 12, Intercrine reduced in hepatomas, Pre-B cell growth-stimulating factor, SDF-1, PBSF, CXCL12 and SDF1, is a secreted protein which belongs to the intercrine alpha (chemokine CxC) family. CXCL12 / SDF-1 is widely expressed in various organs including heart, liver, brain, kidney, skeletal muscle, and lymphoid organs, and is highly conserved between species. CXCL12 / SDF-1 is expressed in two isoforms from a single gene that encodes two splice variants, SDF1α and SDF1β, which are identical except for the four residues present in the C-terminus of SDF1β but absent from SDF1α. As a highly efficacious lymphocyte chemoattractant, CXCL12 / SDF-1 activates and directs the migration of leukocytes in response to proinflammatory stimuli such as LPS, TNF, or interleukins. It has been demonstrated that CXCL12 / SDF-1 promotes tumor growth and malignancy, enhances tumor angiogenesis, participates in tumor metastasis, and thus plays an important role in carcinoma pathogenesis. In addition, CXCL12 / SDF-1 is identified as the biological ligand for CXC-chemokine receptor 4 (CXCR4), which is widely expressed in leukocytes and acts as the cofactor for HIV-1 entry, and inhibits the HIV-1 infection. Furthermore, SDF1 is rapidly inactivated via N-terminal processing by cathepsin G associated with the membrane of B-cells, NK cells and to a lesser extent, T-cells.
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