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Chemokine (C-X-C motif) ligand 10 Protein Datasheet
CXCL10 / Crg-2 Protein Price Inquiry ( Available Sizes )
CXCL10 / Crg-2 Protein Product Information
|Synonym :||CXCL10, INP10, SCYB10|
A DNA sequence encoding the mature form of human CXCL10 (Q9UBH0) (Val22-Pro98) was expressed, with a N-terminal Met.
CXCL10 / Crg-2 Protein QC Testing
|Purity:||> 90 % as determined by SDS-PAGE||SDS-PAGE:
CXCL10 / Crg-2 protein
|Endotoxin:||Please contact us for more information.|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Met|
The recombinant human CXCL10 consists of 78 amino acids and predicts a molecular mass of 8.8 KDa. It migrates as an approximately 9 KDa band in SDS-PAGE under reducing conditions.
|Formulation:||Lyophilized from sterile PBS.
CXCL10 / Crg-2 Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
CXCL10 / Crg-2 Protein Related Products & Topics
CXCL10 / Crg-2 Protein Description
CXCL10, also known as crg-2, belongs to the intercrine alpha (chemokine CxC) family. CXC chemokines are particularly significant for leukocyte infiltration in inflammatory diseases. With a three-dimensional crystal structure, CXCL10’s signaling is mediated by the g protein-coupled receptor CXCR3, which is expressed on activated T cells and plays an important role in directing the migration of T cells, especially during Th1 responses. It is secreted by monocytes, epithelial cells, and endothelial cells in response to IFN gamma or other pro-inflammatory cytokines and stimuli. Binding of CXCL10 to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. It is chemotactic for monocytes and T-lymphocytes. Baseline pre-treatment plasma levels of CXCL10 are elevated in patients chronically infected with hepatitis C virus (HCV) of genotypes 1 or 4.
- O'Donovan N. et al., 1999, Cell Genet. 84 (1-2): 39-42.
- Swaminathan GJ. et al., 2003, Structure. 11 (5): 521-32.
- Booth V. et al., 2002, Biochemistry. 41 (33): 10418-25.