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CXCL10 / Crg-2  Protein, Antibody, ELISA Kit, cDNA Clone

Expression host: E. coli  
10768-HNAE-50
10768-HNAE-100
50 µg 
100 µg 
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CXCL10 / Crg-2 Related Area

CXCL10 / Crg-2 Related Pathways

    CXCL10 / Crg-2 Summary & Protein Information

    CXCL10 / Crg-2 Background

    Gene Summary: CXCL10 gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Jul 2008]
    General information above from NCBI
    Subcellular location: Secreted.
    Induction: By IFNG/IFN-gamma. A diverse population of cell types rapidly increases transcription of mRNA encoding this protein. This suggests that gamma-induced protein may be a key mediator of the IFNG/IFN-gamma response.
    Post-translational: CXCL10(1-73) is produced by proteolytic cleavage after secretion from keratinocytes.
    Sequence similarity: Belongs to the intercrine alpha (chemokine CxC) family.
    General information above from UniProt

    CXCL10, also known as crg-2, is a chemokine of the CXC subfamily and ligand for the receptor CXCR3. CXC chemokines are particularly significant for leukocyte infiltration in inflammatory diseases. CXCL10 has a three-dimensional crystal structure. Its signaling is mediated by the g protein-coupled receptor CXCR3, which is expressed on activated T cells and plays an important role in directing the migration of T cells, especially during Th1 responses. Binding of CXCL10 to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. It is chemotactic for monocytes and T-lymphocytes. CXCL10 can be secreted by several cell types in response to IFN-γ. Baseline pre-treatment plasma levels of CXCL10 are elevated in patients chronically infected with hepatitis C virus (HCV) of genotypes 1 or 4 who do not achieve a sustained viral response (SVR) after completion of antiviral therapy.

    Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    CXCL10 / Crg-2 Alternative Name

    C7,IFI10,INP10,IP-10,crg-2,mob-1,SCYB10,gIP-10, [homo-sapiens]
    10 kDa interferon gamma-induced protein,C7,crg-2,C-X-C motif chemokine 10,gamma IP10,gIP-10,IFI10,INP10,interferon-inducible cytokine IP-10,IP-10,member 10,mob-1,protein 10 from interferon (gamma)-induced cell line,SCYB10,small inducible cytokine subfamily B (Cys-X-Cys),small-inducible cytokine B10, [human]
    10 kDa interferon gamma-induced protein,C7,CRG-2,C-X-C motif chemokine 10,gamma-IP10,gIP-10,Ifi10,INP10,interferon activated gene 10,interferon-gamma induced protein CRG-2,IP10,IP-10,member 10,mob-1,Scyb10,small inducible cytokine B subfamily (Cys-X-Cys),small-inducible cytokine B10, [mouse]
    C7,IP10,CRG-2,INP10,IP-10,Ifi10,mob-1,Scyb10,gIP-10, [mus-musculus]
    IP-10,Scyb10, [Rat]

    CXCL10 / Crg-2 Related Studies

  • O'Donovan N, et al. (1999) Physical mapping of the CXC chemokine locus on human chromosome 4. Cytogenet. Cell Genet. 84(1-2):39-42.
  • Swaminathan GJ, et al. (2003) Crystal structures of oligomeric forms of the IP-10/CXCL10 chemokine. Structure. 11(5):521-32.
  • Booth V, et al. (2002) The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions. Biochemistry. 41(33):10418-25.
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