Anti-IP-10 Antibody

Cat: 10768-RP01
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Anti-IP-10 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-IP-10 Antibody
Validated applications
Species reactivity
Reacts with: Human
Human IP-10
Recombinant Human CXCL10 / Crg-2 protein (Catalog#10768-HNAE)
Produced in rabbits immunized with purified, recombinant Human CXCL10 / Crg-2 (rh CXCL10 / Crg-2; Catalog#10768-HNAE; Q9UBH0; Val22-Pro98). Total IgG was purified by Protein A affinity chromatography.
Polyclonal Rabbit IgG
Protein A
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-IP-10 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-IP-10 Antibody Alternative Names
Anti-C7 Antibody;Anti-crg-2 Antibody;Anti-gIP-10 Antibody;Anti-IFI10 Antibody;Anti-INP10 Antibody;Anti-IP-10 Antibody;Anti-mob-1 Antibody;Anti-SCYB10 Antibody
IP-10 Background Information

CXCL10, also known as crg-2, is a chemokine of the CXC subfamily and ligand for the receptor CXCR3. CXC chemokines are particularly significant for leukocyte infiltration in inflammatory diseases. CXCL10 has a three-dimensional crystal structure. Its signaling is mediated by the g protein-coupled receptor CXCR3, which is expressed on activated T cells and plays an important role in directing the migration of T cells, especially during Th1 responses. Binding of CXCL10 to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. It is chemotactic for monocytes and T-lymphocytes. CXCL10 can be secreted by several cell types in response to IFN-γ. Baseline pre-treatment plasma levels of CXCL10 are elevated in patients chronically infected with hepatitis C virus (HCV) of genotypes 1 or 4 who do not achieve a sustained viral response (SVR) after completion of antiviral therapy.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
chemokine (C-X-C motif) ligand 10
  • O'Donovan N, et al. (1999) Physical mapping of the CXC chemokine locus on human chromosome 4. Cytogenet. Cell Genet. 84(1-2):39-42.
  • Swaminathan GJ, et al. (2003) Crystal structures of oligomeric forms of the IP-10/CXCL10 chemokine. Structure. 11(5):521-32.
  • Booth V, et al. (2002) The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions. Biochemistry. 41(33):10418-25.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-IP-10 Antibody Rabbit Polyclonal ELISA 10768-T16
    Anti-IP-10 Antibody Rabbit Monoclonal ELISA 10768-R121
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