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CXCL1

The Chemokine (C-X-C motif) Ligand 1, CXCL1, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GRO?, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-a). CXCL1 already known to be important in osteoarthritis (OA), as a novel target gene of transcription factor AP-2? in chondrocytes and support the important role of AP-2? in cartilage. CXCL1 is a potent neutrophil chemoattractant with recognized roles in angiogenesis and inflammation. CXCL1 is a novel immediate PTH/PTHrP-responsive gene. CXCL1 may act as a chemoattractant for osteoclast precursors. CXCL1 may also have important pro-nociceptive effects via its direct actions on sensory neurons, and may induce long-term changes that involve protein synthesis. CXCL1 plays a critical nonredundant role in the development of experimental Lyme arthritis and carditis via CXCR2-mediated recruitment of neutrophils into the site of infection. CXCL1 functions through CXCR2 to transactivate the EGFR by proteolytic cleavage of HB-EGF, leading to activation of MAPK signalling and increased proliferation of epithelial ovarian cancer (EOC) cells. It might limit tumor growth by reinforcing senescence early in tumorigenesis. Thus, CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation, wound healing, and tumorigenesis.

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CXCL1 Related Products

CXCL1 Proteins

CXCL1 Antibodies

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CXCL1 ELISA Pair sets

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CXCL1 cDNA Clones

CXCL1 Related Areas

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>CXCL1

Immunology>>Cytokine & Receptor>>Chemokine & Receptor>>CXCL1

CXCL1 Related Pathways

CXCL1 Alternative Names

CXCL1, FSP, GRO1, GROa, MGSA, MGSA-a, NAP-3, SCYB1 [Homo sapiens]

CXCL1, Fsp, Gro1, KC, Mgsa, N51, Scyb1, gro [Mus musculus]

Summaries for CXCL1

Entrez Gene summary for CXCL1:

CXCL1 gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signal through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of CXCL1 gene. A pseudogene of CXCL1 gene is found on chromosome 4.

OMIM - description for CXCL1:

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CXC chemokines are further subdivided into ELR and non-ELR types based on the presence or absence of a glu-leu-arg sequence adjacent and N terminal to the CXC motif. ELR types are chemotactic for neutrophils, while non-ELR types are chemotactic for lymphocytes.

Wikipedia summary for CXCL1:

Chemokine (C-X-C motif) ligand 1 (CXCL1) is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GROα, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-α). In humans, this protein is encoded by the CXCL1 gene.

Human CXCL1 Protein General Information

 

Protein names

C-X-C motif chemokine 1,Short name = CXCL1

Sequence length

107 AA.

Domain

Signal

Sequence similarities:

Belongs to the intercrine alpha (chemokine CxC) family.

Post-translational modification:

N-terminal processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) are produced by proteolytic cleavage after secretion from peripheral blood monocytes.

Subcellular location: Secreted.

General information above from UniProt

Function for CXCL1 Protein

UniProtKB:

CXCL1 has chemotactic activity for neutrophils. CXCL1 may play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity.

Genatlas:

  • CXCL1 is a growth regulator
  • CXCL1 has melanoma growth stimulating activity
  • CXCL1 may play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion
  • CXCL1 is a potent inducer of senescence in stromal fibroblasts (depending on functional TP53), having a role for cell survival and the malignant transformation of ovarian epithelial cells
  • Both CXCL1 and CXCR2 play an important role in chemokine expression and neutrophil infiltration following adenoviral corneal infection, but have a redundant role in the development of keratitis

Homology for human CXCL1

  • homolog to murine Gro1

Phenotype Information for CXCL1

Drugs for CXCL1

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