Anti-CAR Antibody

Cat: 50019-RP02
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Anti-CAR Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-CAR Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Mouse
Specificity
Mouse CAR
Immunogen
Recombinant Mouse CXADR protein (Catalog#50019-M08H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse CXADR (rM CXADR; Catalog#50019-M08H; NP_001020363.1; Met 1-Gly 237). CXADR specific IgG was purified by Mouse CXADR affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CAR Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  
IHC-P 1:500-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CAR Antibody (Rabbit Polyclonal antibody) Images
Mouse CXADR / CAR Immunohistochemistry(IHC) 3317
Immunochemical staining of mouse CXADR in mouse stomach with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Mouse CXADR / CAR Immunohistochemistry(IHC) 3319
Immunochemical staining of mouse CXADR in mouse liver with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).
Anti-CAR Antibody Alternative Names
Anti-2610206D03Rik Antibody;Anti-AU016810 Antibody;Anti-AW553441 Antibody;Anti-CAR Antibody;Anti-MCAR Antibody;Anti-MCVADR Antibody
CAR Background Information

CXADR (coxsackie virus and adenovirus receptor), also known as CAR, is a type I  transmembrane glycoprotein belonging to the CTX family of the Ig superfamily, and is essential for normal cardiac development in the mouse. Proposed as a homophilic cell adhesion molecule, CXADR is a component of the epithelial apical junction complex that is essential for the tight junction integrity, and probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN). Mature mouse CXADR structrually comprises a 218 aa extracellular domain (ECD) with a V-type (D1) and a C2-type (D2) Ig-like domain, a 21 aa transmembrane segment and a 107 aa intracellular domain, among which,D1 is thought to be responsible for homodimer formation in trans within tight junctions. The ECD of mouse CXADR shares 97%, 90% sequence identity with the corresponding regions of rat, human CXADR.

Full Name
coxsackie virus and adenovirus receptor
References
  • Tomko, R.P. et al., 1997, Proc. Natl. Acad. Sci. U.S.A. 94 (7): 3352–3356.
  • van Raaij , M.J. et al., 2001, Structure. 8 (11): 1147–1155.
  • Cohen, C.J. et al., 2001, J. Biol. Chem. 276 (27): 25392–25398.
  • Carson, S.D. et al., 2002, Rev. Med. Virol. 11 (4): 219–226.
  • Selinka, H.C. et al., 2004, Med. Microbiol. Immunol. 193 (2-3): 127–131.
  • Philipson, L. et al., 2004, Curr. Top. Microbiol. Immunol. 273:87-111.
  • Raschperger, E. et al., 2006, Exp. Cell Res. 312: 1566-1580.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CAR Antibody Rabbit Monoclonal ELISA,IHC-P 50019-R001
    Anti-CAR Antibody Rabbit Polyclonal ELISA 50019-RP01
    Anti-CAR Antibody Rabbit Polyclonal ELISA,IHC-P,ICC/IF,IF 10799-T26
    Anti-CAR Antibody Rabbit Polyclonal ELISA 10799-RP01
    Anti-CAR Antibody Rabbit Monoclonal ELISA 10799-R020
    Anti-CAR Antibody Rabbit Monoclonal ELISA(Cap) 10799-R023
    Anti-CAR Antibody Rabbit Monoclonal ELISA(Det),FCM,ICC/IF,IF 10799-R271
    Anti-CAR Antibody (FITC) Rabbit Monoclonal FCM 10799-R271-F
    Anti-CAR Antibody Rabbit Polyclonal ELISA 10799-RP02
    Anti-CAR Antibody Rabbit Monoclonal ELISA 10799-R068
    Anti-CAR Antibody (PE) Rabbit Monoclonal FCM 10799-R271-P
    Anti-CAR Antibody Rabbit Polyclonal ELISA 10799-T16
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