cullin 2/CUL2: cullin 2/CUL2 Protein | cullin 2/CUL2 Antibody

cullin 2/CUL2 Gene family

cullin 2/CUL2 Protein

cullin 2/CUL2 protein function

Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).

cullin 2/CUL2 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    745.00
  • Mass (Da)
    86.00

cullin 2/CUL2 Gene

CUL2 cDNA / gene is a gene with protein product which located on 10p11.21. The CUL2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, and frog. 240 organisms have orthologs with human gene CUL2.