Anti-Cathepsin Z Antibody

Cat: 50089-R009
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Anti-Cathepsin Z Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-Cathepsin Z Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse Cathepsin Z
No cross-reactivity in ELISA with Human CTSZ
Immunogen
Recombinant Mouse CTSZ / CTSX / Cathepsin Z protein (Catalog#50089-M08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CTSZ / CTSX / Cathepsin Z (rM CTSZ / CTSX / Cathepsin Z; Catalog#50089-M08H; NP_071720.1; Met 1-Val 306).
Source
Monoclonal Rabbit IgG Clone #009
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Cathepsin Z Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Cathepsin Z Antibody Alternative Names
Anti-AI787083 Antibody;Anti-AU019819 Antibody;Anti-CTSX Antibody;Anti-D2Wsu143e Antibody
Cathepsin Z Background Information

Cathepsin Z (CTSZ), also known as Cathepsin X or CATX, belongs to the C1 family of lysosomal cysteine proteases. Its gene structure and activity properties show several unique features that distinguish it clearly from other human cysteine proteases. It has a very short pro-region that shows no similarity to those of other cathepsins and a three-residue insertion motif that forms a characteristic ‘mini loop’. Cathepsin Z exhibits mono- and di-peptidase activity at its C-terminus, and in contrast to cathepsin B, it does not act as an endopeptidase. It is restricted to the cells of theimmune system, predominantly monocytes, macrophages and dendritic cells. Cathepsin Z is widely expressed in human tissues, suggesting that this enzyme could be involved in the normal intracellular protein degradation taking place in all cell types. It is capable to cleave regulatory motifs at C-terminus affecting the function of targeted molecules. Cathepsin X may regulate also the maturation of dendritic cells, a process, which is crucial in the initiation of adaptive immunity. Furthermore, higher levels of Cathepsin Z are also found in tumour and immune cells of prostate and gastric carcinomas and inmacrophages of gastric mucosa, especially after infection by Helicobacter pylori. Cathepsin Z is also ubiquitously distributed in cancer cell lines and in primary tumors from different sources, suggesting that this enzyme may participate in tumor progression.

Full Name
cathepsin Z
References
  • Santamara I, et al. (1998) Cathepsin Z, a novel human cysteine proteinase with a short propeptide domain and a unique chromosomal location. J Biol Chem. 273(27): 16816-23.
  • Kos J, et al. (2009) The role of cathepsin X in cell signaling. Cell Adh Migr. 3(2): 164-6.
  • Sevenich L, et al. (2010) Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice. Proc Natl Acad Sci U S A. 107(6): 2497-502.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Cathepsin Z Antibody Rabbit Polyclonal ELISA 50089-T16
    Anti-Cathepsin Z Antibody Mouse Monoclonal ELISA 10159-MM05
    Anti-Cathepsin Z Antibody Rabbit Polyclonal ELISA,IHC-P 10159-T24
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