>Mouse CTNNB1 / Catenin beta-1 Protein (GST Tag)
|Catalog||Size (Price)||Quantity||In Stock||Operation||Other Information|
Catenin (cadherin associated protein), beta 1 Protein Datasheet
CTNNB1 / Catenin beta-1 Protein Price Inquiry ( Available Sizes )
CTNNB1 / Catenin beta-1 Protein Product Information
|Synonym :||CTNNB1, Catnb|
|Protein Construction:||A DNA sequence encoding the mouse CTNNB1 (Q02248) (Met1-Leu781) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.|
|Expression Host:||Baculovirus-Insect cells|
CTNNB1 / Catenin beta-1 Protein QC Testing
|Purity:||> 90 % as determined by SDS-PAGE||SDS-PAGE:
CTNNB1 / Catenin beta-1 protein
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Met|
The recombinant mouse CTNNB1/GST chimera consists of 1018 amino acids and has a calculated molecular mass of 113 kDa. The recombinant protein migrates as an approximately 115 kDa band in SDS-PAGE under reducing conditions.
|Formulation:||Lyophilized from sterile 20mM Tris,500mM NaCl, pH 8.0, 10%gly.
CTNNB1 / Catenin beta-1 Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
CTNNB1 / Catenin beta-1 Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|beta-Catenin/CTNNB1||Human||beta-Catenin/CTNNB1 Protein, Recombinant, with GST Tag||11279-H20B|
|beta-Catenin/CTNNB1||Mouse||beta-Catenin/CTNNB1 Protein, Recombinant, with GST Tag||50592-M20B|
|Molecule||Application||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|Human beta-Catenin/CTNNB1||WB, ELISA||beta-Catenin / CTNNB1 Antibody (Antigen Affinity Purified)||11279-RP02|
CTNNB1 / Catenin beta-1 Protein Description
Catenin beta-1, also known as CTNNB1, is a cytoplasm and nucleus protein which belongs to the beta-catenin family. Catenin beta-1 / CTNNB1 contains 12 ARM repeats. Catenin beta-1 / CTNNB1 is expressed in several hair follicle cell types: basal and peripheral matrix cells, and cells of the outer and inner root sheaths. Catenin beta-1 / CTNNB1 is also expressed in colon. Catenin beta-1 / CTNNB1 is involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. Catenin beta-1 / CTNNB1 is involved in signal transduction through the Wnt pathway. Nuclear beta-catenin is involved in transcriptional regulation by association with transcription factors of the TCF / LEF family. Defects in CTNNB1 are associated with colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB) susceptibility to ovarian cancer (OC).
- Huelsken J.?et al., 1994, J Cell Biol. 127: 2061-9.
- Butz S. et al., 1994, FEBS Lett. 355: 195-200.
- Chan E.F. et al., 1999, Nat Genet. 21: 410-3.
- Kim J-S. et al., 2002, Cancer Res. 62: 2744-8.
- Van Noort M. et al., 2002,Exp Cell Res. 276: 264-72.