CTLA-4/CD152 Protein & Antibody

Cytotoxic T-Lymphocyte-Associated protein 4 / Cluster of Differentiation 152

CTLA-4 / CD152 Products

CTLA-4 / CD152 Protein, Recombinant

Molecule	Species	Description	Cat. No
CTLA-4/CD152	Human	CTLA-4/CD152/Fc Protein, Recombinant	11159-H03H
CTLA-4/CD152	Human	CTLA-4/CD152 Protein, Recombinant	11159-H08H
CTLA-4/CD152	Mouse	CTLA-4/CD152/Fc Protein, Recombinant	50503-M02H
CTLA-4/CD152	Mouse	CTLA-4/CD152 Protein, Recombinant	50503-M08H

CTLA-4 / CD152 Antibody

Molecule	Application	Description	Cat. No
Human CTLA-4/CD152	WB, ELISA	Rabbit Polyclonal Antibody	11159-RP01
Human CTLA-4/CD152	WB, ELISA	CTLA-4 / CD152 Antibody (Antigen Affinity Purified)	11159-RP02
Mouse CTLA-4/CD152	WB, ELISA	CTLA-4 / CD152 Antibody	50503-RP01
Mouse CTLA-4/CD152	WB, ELISA	CTLA-4 / CD152 Antibody (Antigen Affinity Purified)	50503-RP02

CTLA-4 / CD152 Elisa Pair Set

Molecule	Application	Description	Cat. No
Human CTLA-4/CD152	ELISA	CTLA-4 / CD152 Elisa Pair Set	SEK11159

CTLA-4 / CD152 cDNA Clone

Molecule	Species	Description	Cat. No
CTLA-4/CD152	Human	Homo sapiens CTLA-4/CD152 cDNA Clone(NM_005214.3)	HG11159-M
CTLA-4/CD152	Mouse	Mus musculus CTLA-4/CD152 cDNA Clone	MG50503-M

CTLA-4 / CD152 Related Areas

Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>CTLA-4/CD152

Immunology>>Adaptive Immunity>>T Cell>>Regulatory T Cell>>CTLA-4/CD152

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>CTLA-4/CD152

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells / Regulatory T Cells>>CTLA-4/CD152

CTLA-4 / CD152 Alternative Names

CTLA-4, CD152, CTLA4, CD, CELIAC3, GRD4, GSE, ICOS, IDDM12 [Homo sapiens]

Ctla4, Cd152, Ctla-4, CH29-120A16.2, Ly-56 [Mus musculus]

CTLA-4 / CD152 Background

Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD80 (B7-1) and CD86 (B7-2). CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role, CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy. In particular, recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Treg).

CTLA-4 / CD152 Related Studies

1. Slavik JM, et al. (1999) CD28/CTLA-4 and CD80/CD86 families: signaling and function. Immunol Res. 19(1): 1-24.
2. Holmberg D, et al. (2005) CTLA-4 (CD152) and its involvement in autoimmune disease. Autoimmunity. 38(3): 225-33.
3. Chin LT, et al. (2008) Immune intervention with monoclonal antibodies targeting CD152 (CTLA-4) for autoimmune and malignant diseases. Chang Gung Med J. 31(1): 1-15.