Anti-CTLA-4 Antibody

Cat: 50503-RP01
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All CTLA-4 Reagents
Anti-CTLA-4 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-CTLA-4 Antibody
Validated applications
Species reactivity
Reacts with: Mouse
Mouse CTLA-4
Recombinant Mouse CTLA-4 / CD152 protein (Catalog#50503-M08H)
Produced in rabbits immunized with purified, recombinant Mouse CTLA-4 / CD152 (rM CTLA-4 / CD152; Catalog#50503-M08H; NP_033973.2; Met 1-Phe 162). Total IgG was purified by Protein A affinity chromatography.
Polyclonal Rabbit IgG
Protein A
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CTLA-4 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
WB 1:500-1:1000  
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CTLA-4 Antibody (Rabbit Polyclonal antibody) Images
Mouse CTLA-4/CD152 Western blot (WB) 13681

Anti-CTLA4 rabbit polyclonal antibody at 1:500 dilution

Lane A: K562 whole cell lysate

Lane B: Jurkat whole cell lysate

Lysates/proteins at 20 μg per lane.


Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:25 kDa

Observed band size:26 kDa

(We are unsure as to the identity of these extra bands.)

Anti-CTLA-4 Antibody Alternative Names
Anti-Cd152 Antibody;Anti-Ctla-4 Antibody;Anti-Ly-56 Antibody
CTLA-4 Background Information

Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD80 (B7-1) and CD86 (B7-2). CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role, CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy. In particular, recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Treg).

Immune Checkpoint
Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: IP Antibodies   Immune Checkpoint Detection: WB Antibodies
Immune Checkpoint Proteins   CTLA4 / CD152 Immune Checkpoint Proteins
Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
cytotoxic T-lymphocyte-associated protein 4
  • Slavik JM, et al. (1999) CD28/CTLA-4 and CD80/CD86 families: signaling and function. Immunol Res. 19(1): 1-24.
  • Holmberg D, et al. (2005) CTLA-4 (CD152) and its involvement in autoimmune disease. Autoimmunity. 38(3): 225-33.
  • Chin LT, et al. (2008) Immune intervention with monoclonal antibodies targeting CD152 (CTLA-4) for autoimmune and malignant diseases. Chang Gung Med J. 31(1): 1-15.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CTLA-4 Antibody Rabbit Polyclonal ELISA 90213-T16
    Anti-CTLA-4 Antibody Rabbit Polyclonal ELISA 70113-T16
    Anti-CTLA-4 Antibody Rabbit Polyclonal ELISA 90213-RP01
    Anti-CTLA-4 Antibody Rabbit Polyclonal WB,ELISA 90213-T48
    Anti-CTLA-4 Antibody Rabbit Polyclonal ELISA 70113-RP01
    Anti-CTLA-4 Antibody Rabbit Polyclonal ELISA 81069-RP01
    Anti-CTLA-4 Antibody Rabbit Polyclonal ELISA 81069-T16
    Anti-CTLA-4 Antibody Rabbit Monoclonal ELISA 50503-R037
    Anti-CTLA-4 Antibody Rabbit Polyclonal WB,ELISA,IP 50503-RP02
    Anti-CTLA-4 Antibody Rabbit Polyclonal ELISA 50503-T16
    Anti-CTLA-4 Antibody Rabbit Polyclonal WB,ELISA 11159-T48
    Anti-CTLA-4 Antibody Rabbit Monoclonal ELISA 11159-R060
    Anti-CTLA-4 Antibody Rabbit Polyclonal ELISA 11159-RP01
    Anti-CTLA-4 Antibody Rabbit Polyclonal ELISA 11159-T16
    Anti-CTLA-4 Antibody Mouse Monoclonal ELISA,ELISA(Cap) 11159-MM06
    Anti-CTLA-4 Antibody Rabbit Polyclonal WB,ELISA 11159-RP02
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