Anti-CTLA-4 Antibody

Cat: 11159-RP02
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All CTLA-4 Reagents
Anti-CTLA-4 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-CTLA-4 Antibody
Validated applications
WB,ELISA
Species reactivity
Reacts with: Human
Specificity
Human CTLA-4
Immunogen
Recombinant Human CTLA-4 / CD152 protein (Catalog#11159-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human CTLA-4 / CD152 (rh CTLA-4 / CD152; Catalog#11159-H08H; NP_005205.2; Met 1-Phe 162). CTLA-4 / CD152 specific IgG was purified by Human CTLA-4 / CD152 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CTLA-4 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
WB 1:500-1:1000  
ELISA 1:25000-1:50000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CTLA-4 Antibody (Rabbit Polyclonal antibody) Images
Human CTLA-4/CD152 Western blot (WB) 13355

Anti-CTLA4 rabbit polyclonal antibody at 1:500 dilution

Lane A: Jurkat Membrane Lysate

Lysates/proteins at 20 μg per lane.

Secondary

Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:25 kDa

Observed band size:31 kDa

Anti-CTLA-4 Antibody Alternative Names
Anti-ALPS5 Antibody;Anti-CD Antibody;Anti-CD152 Antibody;Anti-CELIAC3 Antibody;Anti-CTLA-4 Antibody;Anti-GRD4 Antibody;Anti-GSE Antibody;Anti-IDDM12 Antibody
CTLA-4 Background Information

Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD80 (B7-1) and CD86 (B7-2). CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role, CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy. In particular, recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Treg).

Immune Checkpoint
Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: IP Antibodies   Immune Checkpoint Detection: WB Antibodies
Immune Checkpoint Proteins   CTLA4 / CD152 Immune Checkpoint Proteins
Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
cytotoxic T-lymphocyte-associated protein 4
References
  • Slavik JM, et al. (1999) CD28/CTLA-4 and CD80/CD86 families: signaling and function. Immunol Res. 19(1): 1-24.
  • Holmberg D, et al. (2005) CTLA-4 (CD152) and its involvement in autoimmune disease. Autoimmunity. 38(3): 225-33.
  • Chin LT, et al. (2008) Immune intervention with monoclonal antibodies targeting CD152 (CTLA-4) for autoimmune and malignant diseases. Chang Gung Med J. 31(1): 1-15.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CTLA-4 Antibody Rabbit Polyclonal ELISA 90213-T16
    Anti-CTLA-4 Antibody Rabbit Polyclonal WB,ELISA 90213-T48
    Anti-CTLA-4 Antibody Rabbit Polyclonal ELISA 70113-RP01
    Anti-CTLA-4 Antibody Rabbit Polyclonal ELISA 90213-RP01
    Anti-CTLA-4 Antibody Rabbit Polyclonal ELISA 70113-T16
    Anti-CTLA-4 Antibody Rabbit Polyclonal ELISA 81069-T16
    Anti-CTLA-4 Antibody Rabbit Polyclonal ELISA 81069-RP01
    Anti-CTLA-4 Antibody Rabbit Polyclonal WB,ELISA 50503-RP01
    Anti-CTLA-4 Antibody Rabbit Polyclonal WB,ELISA,IP 50503-RP02
    Anti-CTLA-4 Antibody Rabbit Monoclonal ELISA 50503-R037
    Anti-CTLA-4 Antibody Rabbit Polyclonal ELISA 50503-T16
    Anti-CTLA-4 Antibody Rabbit Polyclonal ELISA 11159-T16
    Anti-CTLA-4 Antibody Rabbit Polyclonal ELISA 11159-RP01
    Anti-CTLA-4 Antibody Rabbit Polyclonal WB,ELISA 11159-T48
    Anti-CTLA-4 Antibody Rabbit Monoclonal ELISA 11159-R060
    Anti-CTLA-4 Antibody Mouse Monoclonal ELISA,ELISA(Cap) 11159-MM06
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