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CTLA-4 / CD152 Antibody, Rabbit PAb

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Human CTLA4 Antibody Product Information
Immunogen:Recombinant Human CTLA4 protein (Catalog#11159-H08H)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Human CTLA4 extracellular domain (rh CTLA4; Catalog#11159-H08H; NP_005205.2; Met 1-Phe 162). Total IgG was purified by Protein A affinity chromatography .
Human CTLA4 Antibody Usage Guide
Specificity:Human CTLA4 / CD152
Application:ELISA

ELISA: 0.5-1.0 μg/mL

This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Human CTLA4. The detection limit for Human CTLA4 is 0.00245 ng/well.

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Other CTLA4 Antibody Products
Reactivity: Human  
Application: ELISA  
    11159-R060-50
    11159-R060-100
    50 µg 
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    Reactivity: Human  
    Application: ELISA  WB  
    • Slide 1
    11159-T48-200
    11159-T48-100
    11159-T48-50
    200 µg 
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    Reactivity: Human  
    Application: ELISA  WB  
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    11159-RP02-200
    11159-RP02-50
    11159-RP02-100
    200 µg 
    50 µg 
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    Reactivity: Human  
    Application: ELISA  
      11159-MM06-200
      11159-MM06-50
      11159-MM06-100
      200 µg 
      50 µg 
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      Reactivity: Human  
      Application: ELISA  
        11159-T16-50
        11159-T16-200
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        50 µg 
        200 µg 
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        Reactivity: Mouse  
        Application: ELISA  
          50503-R037-50
          50503-R037-100
          50 µg 
          100 µg 
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          Reactivity: Mouse  
          Application: ELISA  WB  
          • Slide 1
          50503-RP01-100
          50503-RP01-200
          50503-RP01-400
          100 µg 
          200 µg 
           
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          Reactivity: Mouse  
          Application: ELISA  WB  IP  
          • Slide 1
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          50503-RP02-200
          50503-RP02-50
          50503-RP02-100
          200 µg 
          50 µg 
          100 µg 
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          Reactivity: Rat  
          Application: ELISA  
            81069-RP01-400
            81069-RP01-100
            81069-RP01-200
             
            100 µg 
            200 µg 
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            Reactivity: Rat  
            Application: ELISA  
              81069-T16-50
              81069-T16-100
              81069-T16-200
              50 µg 
              100 µg 
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              Reactivity: Cynomolgus  
              Application: ELISA  WB  
              • Slide 1
              90213-T48-100
              90213-T48-200
              90213-T48-50
              100 µg 
              200 µg 
              50 µg 
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              Reactivity: Cynomolgus  
              Application: ELISA  
                90213-RP01-200
                90213-RP01-100
                90213-RP01-400
                200 µg 
                100 µg 
                 
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                Reactivity: Canine  
                Application: ELISA  
                  70113-T16-100
                  70113-T16-50
                  70113-T16-200
                  100 µg 
                  50 µg 
                  200 µg 
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                  Reactivity: Canine  
                  Application: ELISA  
                    70113-RP01-400
                    70113-RP01-200
                    70113-RP01-100
                     
                    200 µg 
                    100 µg 
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                    CTLA-4/CD152 Background

                    Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD80 (B7-1) and CD86 (B7-2). CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role, CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy. In particular, recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Treg).

                    Human CTLA-4/CD152 References
                  • Slavik JM, et al. (1999) CD28/CTLA-4 and CD80/CD86 families: signaling and function. Immunol Res. 19(1): 1-24.
                  • Holmberg D, et al. (2005) CTLA-4 (CD152) and its involvement in autoimmune disease. Autoimmunity. 38(3): 225-33.
                  • Chin LT, et al. (2008) Immune intervention with monoclonal antibodies targeting CD152 (CTLA-4) for autoimmune and malignant diseases. Chang Gung Med J. 31(1): 1-15.
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                    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
                    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"