Anti-CTHRC1 Antibody

Cat: 11647-RP02
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Anti-CTHRC1 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-CTHRC1 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human CTHRC1
Immunogen
Recombinant Human CTHRC1 protein (Catalog#11647-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human CTHRC1 (rh CTHRC1; Catalog#11647-H08H; NP_612464.1; Met 1-Lys 243). CTHRC1 specific IgG was purified by Human CTHRC1 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CTHRC1 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

CTHRC1 Background Information

Collagen triple helix repeat-containing protein 1, also known as Protein NMTC1, and CTHRC1, is a secreted protein that is glycosylated and highly conserved from lower chordates to mammals. CTHRC1 expression was not detectable in normal arteries. However, it is transiently expressed in the arterial wall in response to injury where it may contribute to vascular remodeling by limiting collagen matrix deposition and promoting cell migration. A short collagen motif with 12 Gly-X-Y repeats appears to be responsible for trimerization of the CTHRC1 protein and this renders the molecule susceptible to cleavage by collagenase. CTHRC1 overexpression caused a dramatic reduction in collagen type I mRNA and protein levels. Currently available data indicate that Cthrc1 expression in vascular cells regulates transforming growth factor beta responsiveness, thereby impacting transforming growth factor beta target genes, including collagens. Additionally, CTHRC1 increases bone mass as a positive regulator of osteoblastic bone formation and offers an anabolic approach for the treatment of osteoporosis.

Full Name
collagen triple helix repeat containing 1
References
  • Pyagay P, et al. (2005) Collagen triple helix repeat containing 1, a novel secreted protein in injured and diseased arteries, inhibits collagen expression and promotes cell migration. Circ Res. 96(2): 261-8.
  • Durmus T, et al. (2006) Expression analysis of the novel gene collagen triple helix repeat containing-1 (Cthrc1). Gene Expr Patterns. 6(8): 935-40.
  • LeClair R, et al. (2007) The role of collagen triple helix repeat containing 1 in injured arteries, collagen expression, and transforming growth factor beta signaling. Trends Cardiovasc Med. 17(6): 202-5.
  • Kimura H, et al. (2008) Cthrc1 is a positive regulator of osteoblastic bone formation. PLoS One. 3(9): e3174.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CTHRC1 Antibody Rabbit Polyclonal ELISA 80712-T16
    Anti-CTHRC1 Antibody Rabbit Monoclonal ELISA 11647-R062
    Anti-CTHRC1 Antibody Rabbit Monoclonal WB,IP 11647-R166
    Anti-CTHRC1 Antibody Rabbit Polyclonal ELISA 11647-T16
    Anti-CTHRC1 Antibody Rabbit Monoclonal ELISA(Cap) 11647-R055
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