CSNK2A2

Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV.

CSNK2A2 Related Areas

Enzyme>>Protein Kinase>>Intracellular Kinase>>CSNK2A2

Signal Transduction>>Protein Kinase>>Intracellular Kinase>>CSNK2A2

Stem Cell>>Wnt Signaling Pathway>>Non-Canonical Wnt Pathway>>CSNK2A2

Neuroscience>>Axon Guidance>>Wnt Signaling Pathway>>CSNK2A2

CSNK2A2 Alternative Names

CSNK2A2, CK2A2, CSNK2A1, FLJ43934 [Homo sapiens]

Csnk2a2, 1110035J23Rik, C77789, CK2 [Mus musculus]

Summaries for CSNK2A2

Entrez Gene summary for CSNK2A2:

OMIM - description for CSNK2A2:

By somatic cell hybrid analysis, Yang-Feng et al. (1991) demonstrated that the CK2A2 gene maps to chromosome 16. By in situ hybridization, Yang-Feng et al. (1994) mapped the CSNK2A2 gene to 16p13.3-p13.2. (In the title and body of the article, Yang-Feng et al. (1994) incorrectly referred to the gene in question as CSNK2A1; CSNK2A1

Wikipedia summary for CSNK2A2:

Casein kinase II subunit alpha' is an enzyme that in humans is encoded by the CSNK2A2 gene

Human CSNK2A2 Protein General Information

 

• Protein names: Recommended name: Casein kinase II subunit alpha' Short name=CK II alpha'
• Sequence length: 350 AA.
• Sequence similarities: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily. Contains 1 protein kinase domain. Ontologies
• Miscellaneous: Can use both ATP and GTP as phosphoryl donors. Phosphorylation by casein kinase 2 has been estimated to represent up to one quarter of the eukaryotic phosphoproteome.
• Subunit structure: Heterotetramer composed of two catalytic subunits (alpha chain and/or alpha' chain) and two regulatory subunits (beta chains). The tetramer can exist as a combination of 2 alpha/2 beta, 2 alpha'/2 beta or 1 alpha/1 alpha'/2 beta subunits. Also part of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, which forms following UV irradiation. Interacts with RNPS1.
• Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
• Enzyme regulation: Constitutively active protein kinase whose activity is not directly affected by phosphorylation. Seems to be regulated by level of expression and localization

General information above from UniProt

Function for CSNK2A2 Protein

UniProtKB:

Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV.

Genatlas:

• CSNK2A2 is involved in regulation of cell growth
• CSNK2A1 and PRPF3 are absolutely necessary for an efficient splicing whereas CSNK2A2 seems to be dispensable
• involved, among a wide variety of cellular processes, in the maintenance of mammalian cell morphology and cell polarity
• CSNK2A2 protects against ionizing radiation-induced apoptosis partly by phosphorylating and activating SIRT1
• CSNK2A1, CSNK2A2 and microtubules control axon initial segment formation

Homology for human CSNK2A2

• ortholog to bovine csnk2a prime
• ortholog to murine Csnk2a2