CSNK1A1

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May play a role in segregating chromosomes during mitosis.

CSNK1A1 Related Areas

Enzyme>>Protein Kinase>>Intracellular Kinase>>CSNK1A1

Signal Transduction>>Protein Kinase>>Intracellular Kinase>>CSNK1A1

Stem Cell>>Wnt Signaling Pathway>>Non-Canonical Wnt Pathway>>CSNK1A1

Neuroscience>>Axon Guidance>>Wnt Signaling Pathway>>CSNK1A1

CSNK1A1 Alternative Names

CSNK1A1, CK1, HLCDGP1, PRO2975, CKI-alpha [Homo sapiens]

Csnk1a1, 2610208K14Rik, 4632404G05Rik, 5430427P18Rik, CK1a, Csnk1a, MGC29354, MGC30571, CK1, CKI-alpha [Mus musculus]

Summaries for CSNK1A1

Entrez Gene summary for CSNK1A1:

Tapia et al. (1994) isolated a cDNA encoding human casein kinase I from a fetal brain library using PCR primers based on the bovine sequence. The cDNA was sequenced and shown to have a predicted amino acid sequence identical to the bovine protein except that it contains 12 additional amino acids at the carboxyl end.

OMIM - description for CSNK1A1:

Wikipedia summary for CSNK1A1:

Casein kinase I isoform alpha is an enzyme that in humans is encoded by the CSNK1A1 gene

Human CSNK1A1 Protein General Information

 

• Protein names: Recommended name: Casein kinase I isoform alpha Short name=CKI-alpha
• Sequence length: 337 AA.
• Sequence similarities: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. Contains 1 protein kinase domain.
• Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
• Subunit structure: Monomer. Interacts with the Axin complex. Interacts with TUT1, leading to TUT1 phosphorylation
• Subcellular location: Cytoplasm. Cytoplasm › cytoskeleton › centrosome. Chromosome › centromere › kinetochore. Nucleus speckle. Note: Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis.

General information above from UniProt

Function for CSNK1A1 Protein

UniProtKB:

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May play a role in segregating chromosomes during mitosis.

Genatlas:

• casein kinase 1, catalytic unit alpha 1, involved in the regulation of the G1-checkpoint at the cyclin-dependent kinase inhibitor CDKN1A
• another kinase that regulates RIPK1 function in NF-kappaB activation
• CSNK1A1 plays a major role in the phosphorylation of TP53 at threonine residue (Thr18) within the Mdm2/4-binding domain
• CSNK1A1 functions as a conditionally essential malignancy gene-a member of a new class of potential cancer therapeutic targets
• CSNK1A1 regulates several fundamental cellular processes including proliferation and differentiation
• nuclear form playing a critical role in vascular cell proliferation, cellular activation, and hydrogen peroxide-mediated mitogenic signal transduction