CSF1R / CD115 Protein & Antibody (MCSF Recptor)

Colony Stimulating Factor 1 Receptor / Cluster of Differentiation 115 (Macrophage Colony Stimulating Factor I Receptor)

CSF1R / CD115 Products

CSF1R / CD115 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CSF1R/MCSF Receptor/CD115	Human	CSF1R/MCSFR/CD115/Fc Protein, Recombinant	10161-H03H
CSF1R/MCSF Receptor/CD115	Human	CSF1R/MCSFR/CD115 Protein, Recombinant	10161-H08H
CSF1R/MCSF Receptor/CD115	Human	CSF1R / M-CSFR / CD115 Protein, Recombinant, with GST Tag	10161-H20B1
CSF1R/MCSF Receptor/CD115	Human	CSF1R/MCSFR/CD115 Protein, Recombinant, with GST Tag	10161-H20B2
CSF1R/MCSF Receptor/CD115	Human	CSF1R/MCSFR/CD115 Protein, Recombinant	10161-HCCH
CSF1R/MCSF Receptor/CD115	Mouse	CSF1R/MCSFR/CD115 Protein, Recombinant	50059-M08H

CSF1R / CD115 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human CSF1R/MCSF Receptor/CD115	WB, ELISA	Mouse Monoclonal Antibody	10161-MM12
Human CSF1R/MCSF Receptor/CD115	WB, ELISA	Mouse Monoclonal Antibody	10161-MM02
Human CSF1R/MCSF Receptor/CD115	WB, ELISA	Rabbit Monoclonal Antibody	10161-R108
Human CSF1R/MCSF Receptor/CD115	WB, ELISA	Rabbit Polyclonal Antibody	10161-RP01
Human CSF1R/MCSF Receptor/CD115	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10161-RP03
Mouse CSF1R/MCSF Receptor/CD115	WB, ELISA	CSF1R / MCSF Receptor / CD115 Antibody	50059-RP01
Mouse CSF1R/MCSF Receptor/CD115	WB, ELISA	CSF1R / MCSF Receptor / CD115 Antibody (Antigen Affinity Purified)	50059-RP02

CSF1R / CD115 ELISA Kit

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human CSF1R/MCSF Receptor/CD115	ELISA	CSF1R/MCSF Receptor/CD115 ELISA Kit	SEK10161

CSF1R / CD115 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CSF1R/MCSF Receptor/CD115	Human	Homo sapiens CSF1R/MCSF Receptor/CD115 cDNA Clone(NM_005211.2)	HG10161-M
CSF1R/MCSF Receptor/CD115	Mouse	Mus musculus CSF1R/MCSF Receptor/CD115 cDNA Clone	MG50059-M

CSF1R / CD115 Alternative Names

CSF1R, CD115, CSFR, C-FMS, FIM2, FMS [Homo sapiens]

Csf1r, M-CSFR, CD115, CSF-1R, AI323359, Csfmr, Fim-2, Fms [Mus musculus]

Csf1r, CSF-1-R, MGC125014, c-fms [Rattus norvegicus]

CSF1R / CD115 Related Areas

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>CSF1R/MCSF Receptor/CD115

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>CSF1R/MCSF Receptor/CD115

Cancer>>Growth Factor & Receptor>>CSF & Receptor>>CSF1R/MCSF Receptor/CD115

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>CSF1R/MCSF Receptor/CD115

Immunology>>Cytokine & Receptor>>CSF & Receptor>>CSF1R/MCSF Receptor/CD115

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Monocyte Markers>>CSF1R/MCSF Receptor/CD115

Immunology>>Cluster of Differentiation>>Granulocyte CD Antigen>>Neutrophils>>CSF1R/MCSF Receptor/CD115

CSF1R / CD115 Background

M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein is consisted by an extracellular ligand-binding domain, a single membrane-spanning segment, and an intracellular tyrosine kinase domain. Binding of CSF1 activates the receptor kinase, leading to "autophosphorylation" of receptor subunits and the concomitant phosphorylation of a series of cellular proteins on tyrosine residues. CSF1R is a tyrosine kinase receptor that is absolutely required for macrophage differentiation and thus occupies a central role in hematopoiesis. CSF1 and its receptor (CSF1R, product of c-fms proto-oncogene) were initially implicated as essential for normal monocyte development as well as for trophoblastic implantation. This apparent role for CSF1/CSF1R in normal mammary gland development is very intriguing because this receptor/ligand pair has also been found to be important in the biology of breast cancer in which abnormal expression of CSF1 and its receptor correlates with tumor cell invasiveness and adverse clinical prognosis. Tumor cell expression of CSF1R is under the control of several steroid hormones (glucocorticoids and progestins) and the binding of several bHLH transcription factors, while tumor cell expression of CSF-1 appears to be regulated by other hormones, some of which are involved in normal lactogenic differentiation. However, studies have demonstrated that CSF1 and CSF1R have additional roles in mammary gland development during pregnancy and lactation. The role of CSF1 and CSF1R in normal and neoplastic mammary development that may elucidate potential relationships of growth factor-induced biological changes in the breast during pregnancy and tumor progression.

CSF1R / CD115 Related Studies

1. Sherr CJ. (1990) The colony-stimulating factor 1 receptor: pleiotropy of signal-response coupling. Lymphokine Res. 9(4): 543-8.
2. Kacinski BM. (1997) CSF-1 and its receptor in breast carcinomas and neoplasms of the female reproductive tract. Mol Reprod Dev. 46(1): 71-4.
3. Sapi E, et al. (1999) The role of CSF-1 in normal and neoplastic breast physiology. Proc Soc Exp Biol Med. 220(1): 1-8.
4. Sapi E. (2004) The role of CSF-1 in normal physiology of mammary gland and breast cancer: an update. Exp Biol Med (Maywood). 229(1): 1-11.
5. Bonifer C, et al. (2008) The transcriptional regulation of the Colony-Stimulating Factor 1 Receptor (csf1r) gene during hematopoiesis. Front Biosci. 13: 549-60.