Anti-CRTAM Antibody

Cat: 11975-RP02
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Anti-CRTAM Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-CRTAM Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human CRTAM
Immunogen
Recombinant Human CRTAM protein (Catalog#11975-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human CRTAM (rh CRTAM; Catalog#11975-H08H; NP_062550.2; Met 1-Ser 286). CRTAM specific IgG was purified by human CRTAM affinity chromatography .
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CRTAM Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CRTAM Antibody Alternative Names
Anti-CD355 Antibody
CRTAM Background Information

Cytotoxic and regulatory T-cell molecule, also known as Class-I MHC-restricted T-cell-associated molecule and CRTAM, is a single-pass type I  membrane protein which belongs to the nectin family. CRTAM contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. In the immune system, the expression of CRTAM is restricted to activated class-I MHC-restricted cells, including NKT and CD8 cells. It is strongly expressed in spleen, thymus, small intestine, peripheral blood leukocyte, and in purkinje neurons in cerebellum. It is expressed at much lower levels in testis, ovary, colon, lung and lymphoid tissues. CRTAM is a member of the immunoglobulin superfamily that complies with the structural characteristics of the JAM family of proteins and is phylogenetically more closely related to nectin-like proteins. It is a molecule involved in epithelial cell adhesion. CRTAM is sensitive to intermediate filament disruption and treatment of monolayers with soluble CRTAM enhances cell-cell dissociation and lowers transepithelial electrical resistance. CRTAM may also induce retention by binding to CD8+ dendritic cells (DCs) at the late stage of activation before proliferation. 

Full Name
cytotoxic and regulatory T cell molecule
References
  • Garay, E. et al., 2010, J Cell Biochem. 111 (1):111-22.
  • Medina-C.O. et al., 2010, Dev Comp Immunol. 34 (2):196-202.
  • Takeuchi, A. et al., 2009, J Immunol.183 (7):4220-8.
  • Valle-Rios,R. et al., 2009, Mol Immunol. 46 (16): 3379-87.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CRTAM Antibody Mouse Monoclonal FCM 11975-MM12
    Anti-CRTAM Antibody Rabbit Polyclonal ELISA 11975-T16
    Anti-CRTAM Antibody Mouse Monoclonal ELISA 11975-MM06
    Anti-CRTAM Antibody (APC) Mouse Monoclonal FCM 11975-MM08-A
    Anti-CRTAM Antibody (PE) Mouse Monoclonal FCM 11975-MM12-P
    Anti-CRTAM Antibody Rabbit Polyclonal ELISA 11975-RP01
    Anti-CRTAM Antibody (APC) Mouse Monoclonal FCM 11975-MM12-A
    Anti-CRTAM Antibody Mouse Monoclonal FCM 11975-MM08
    Anti-CRTAM Antibody (PE) Mouse Monoclonal FCM 11975-MM08-P
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