|Recombinant Rat CRP / C-Reactive Protein protein (Catalog#80041-R08H)|
|0.2 μm filtered solution in PBS|
|Produced in rabbits immunized with purified, recombinant Rat CRP / C-Reactive Protein (rR CRP / C-Reactive Protein; Catalog#80041-R08H; NP_058792.1; Met 1-Ser 230). CRP / C-Reactive Protein specific IgG was purified by Rat CRP / C-Reactive Protein affinity chromatography.|
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Rat CRP. The detection limit for Rat CRP is approximately 0.00975 ng/well.
C-reactive protein (CRP) is synthesized by the liver in response to factors released by fat cells. It is a member of the pentraxin family of proteins. The levels of CRP rise in response to inflammation. Human C-reactive protein (CRP) is the classical acute phase reactant, the circulating concentration of which rises rapidly and extensively in a cytokine-mediated response to tissue injury, infection and inflammation. Serum CRP values are routinely measured, empirically, to detect and monitor many human diseases. However, CRP is likely to have important host defence, scavenging and metabolic functions through its capacity for calcium-dependent binding to exogenous and autologous molecules containing phosphocholine (PC) and then activating the classical complement pathway. CRP may also have pathogenic effects and the recent discovery of a prognostic association between increased CRP production and coronary atherothrombotic events is of particular interest.