All CREB3L1 reagents are produced in house and quality controlled, including 2 CREB3L1 Antibody, 1 CREB3L1 Gene, 1 CREB3L1 Lysate, 1 CREB3L1 Protein. All CREB3L1 reagents are ready to use.
Recombinant CREB3L1 proteins are expressed by HEK293 Cells with fusion tags as C-His.
CREB3L1 antibodies are validated with different applications, which are ELISA.
CREB3L1 cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each CREB3L1 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
CREB3L1, also known as OASIS, is a cellular transcription factor synthesized as a membrane-bound precursor. It is a putative endoplasmic reticulum (ER) stress sensor in astrocytes with a mechanism of activation. OASIS mRNA expression was detected in pancreatic β-cell lines and rodent islets, and the expression level was up-regulated by ER stress-inducing compounds. CREB3L1 may have a role in pancreas development. CREB3L1 may also play an important role in limiting virus spread by inhibiting proliferation of virus-infected cells. In vitro, CREB3L1 binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE. It may play a role in gliosis.
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Vellanki. et al., 2010, Endocrinology. 151 (9): 4146.