CREB: CREB Protein | CREB Antibody

CREB Gene family

CREB Background

CAMP responsive element binding protein 1, also known as CREB-1, plays multiple functions as a transcription factor in gene regulation. This protein is a CREB transcription factor that is a member of the leucine zipper family of DNA-binding proteins. CREB1 proteins are also known to be expressed in several spliced isoforms that act as transcriptional activators or repressors. The activator isoforms, possessing the functional domains for kinase induction and for interaction with other transcriptional regulators, act as transcriptional activators.The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. CREB-1 has a complex influence on behavioural responses to drugs of abuse which varies depending on the brain region in which it is expressed. CREB-1 is important for serotonin (5-HT)-induced long-term facilitation (LTF) of the sensorimotor synapse in Aplysia. 

Reference for CREB

  • Sadamoto H, et al. (2011) Direct observation of dimerization between different CREB1 isoforms in a living cell. PLoS One. 6 (6): e20285.
  • Liu RY, et al. (2011) The requirement for enhanced CREB1 expression in consolidation of long-term synaptic facilitation and long-term excitability in sensory neurons of Aplysia. J Neurosci. 31 (18): 6871-9.
  • Hoeffler JP, et al. (1988) Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA. Science. 242 (4884): 1430-3.

CREB Protein

CREB protein function

Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.

CREB protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    341.00
  • Mass (Da)
    36.00

CREB Antibody

There are 5 CREB antibodies which are validated in multiple tissues with various applications, including ICC/IF, FCM, ELISA, IHC-P. There are 2 CREB antibody for ICC/IF, 1 CREB antibody for FCM, 2 CREB antibody for ELISA, 2 CREB antibody for IHC-P. Among all these CREB antibodies, there are 2 anti-CREB mouse monoclonal antibodies , 3 anti-CREB rabbit polyclonal antibodies . All the CREB anbodies are produced in house and all are in stock. CREB antibody customerized service is available.

CREB Gene

CREB1 gene / cDNA is a protein-coding gene which located on 2q33.3. The CREB1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.223 organisms have orthologs with human gene CREB1.