CRADD (RAIDD)

Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex

CRADD (RAIDD) Related Areas

Cancer>>Apoptosis>>Death Receptor & Ligand>>CRADD (RAIDD)

Signal Transduction>>Adaptor Protein>>CRADD (RAIDD)

CRADD (RAIDD) Alternative Names

CRADD, RAIDD, MGC9163 [Homo sapiens]

Cradd, RAIDD [Mus musculus]

Summaries for CRADD (RAIDD)

Entrez Gene summary for CRADD (RAIDD):

The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins.

OMIM - description for CRADD (RAIDD):

Caspases are a family of cysteine proteases related to ICE (147678) and represent the effector arm of the cell death pathway. In metazoan cells, caspases exist as inactive polypeptide precursors (zymogens), each of which is composed of a large and small catalytic subunit and a prodomain, which is cleaved to activate the protease. Adaptor molecules containing protein-protein interaction motifs are thought to mediate the coupling of these death proteases to signaling pathways. Duan and Dixit (1997) isolated cDNAs encoding such an adaptor molecule, which they designated RAIDD (RIP-associated ICH1/CED3-homologous protein with a death domain). The predicted 199-amino acid protein contained an N-terminal domain (NTD) homologous to the prodomain of ICH1 (CASP2; 600639) and a death domain (DD) similar to that found in RIP (603453). The NTD mediated the binding of RAIDD to ICH1 in vitro and in vivo. RAIDD specifically bound RIP, but not the DD-containing receptors FAS (134637) or TNFR1 (191190), or the DD-containing receptor-associated proteins FADD (602457) or TRADD (603500). However, coimmunoprecipitation studies indicated that TNFR1 complexed with RAIDD in the presence of TRADD and RIP, and through RAIDD, ICH1 was recruited to the signaling complex. Overexpression of RAIDD in mammalian cells induced apoptosis. Duan and Dixit (1997) concluded that RAIDD can function as an adaptor molecule in recruiting the death protease ICH1 to the TNFR1 signaling complex. Northern blot analysis revealed that RAIDD is expressed ubiquitously as a 1.35-kb mRNA. Independently, Ahmad et al. (1997) cloned cDNAs encoding RAIDD, which they called CRADD for 'caspase and RIP adaptor with death domain.' Using in vitro binding studies, they found that CRADD interacted specifically with RIP and CASP2.

Wikipedia summary for CRADD (RAIDD):

Death domain-containing protein CRADD is a protein that in humans is encoded by the CRADD gene. The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins

Human CRADD (RAIDD) Protein General Information

 

• Protein names: Recommended name: Death domain-containing protein CRADD
• Sequence length: 199 AA.
• Domain: Contains a death domain involved in the binding of RIP protein.

  The CARD domain mediates the interaction with caspase-2.

• Sequence similarities: Contains 1 CARD domain. Contains 1 death domain.
• Subunit structure: Interacts with PIDD.
• Subcellular location: Cytoplasm. Nucleus.

General information above from UniProt

Function for CRADD (RAIDD) Protein

UniProtKB:

Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex

Genatlas:

• a N terminal domain highly homolog of two ICE1/CED3 members CASP2 and CASP3
• a N terminal DEATH domain that binds to the homologous domain of RIP a serine/threonine kinase component of the death pathway

Homology for human CRADD (RAIDD)

• homolog to murine Cradd
• homolog to C.elegans f07d10.7

Phenotype Information for CRADD (RAIDD)

• Gene/Locus: CRADD, RAIDD, MRT34
• Phenotype: Mental retardation, autosomal recessive 34

Phenotype Information for CRADD (RAIDD) from OMIM (Online Mendelian Inheritance in Man)