Text Size:AAA

CRADD/RAIDD Protein, Antibody, ELISA Kit, cDNA Clone

CRADD/RAIDD Related Areas

CRADD/RAIDD Related Pathways

CRADD/RAIDD Related Product

    CRADD/RAIDD Summary & Protein Information

    CRADD/RAIDD Background

    Gene Summary: The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins.
    General information above from NCBI
    Subunit structure: Interacts with PIDD.
    Domain: Contains a death domain involved in the binding of RIP protein.
    The CARD domain mediates the interaction with caspase-2.
    Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity).
    Tissue specificity: Constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney.
    Involvement in disease: Mental retardation, autosomal recessive 34 (MRT34) [MIM:614499]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRT34 is a non-syndromic form. Affected individuals have mildly delayed development and significantly impaired cognitive function, precluding independent living and self-care. Speech is rudimentary, but articulate; autism is not present. Note=The disease is caused by mutations affecting the gene represented in this entry.
    Sequence similarity: Contains 1 CARD domain.
    Contains 1 death domain.C
    General information above from UniProt

    Death domain-containing protein CRADD, also known as Caspase and RIP adapter with death domain, RIP-associated protein with a death domain, CRADD and RAIDD, is a protein which is constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney. CRADD / RAIDD contains one CARD domain and one death domain. CRADD / RAIDD contains a death domain involved in the binding of RIP protein. The CARD domain mediates the interaction with caspase-2. FADD / MORT1 is a death domain (DD)-containing adaptor / signaling molecule that interacts with the intracellular DD of FAS / APO-I ( CD95 ) and tumor necrosis factor receptor 1 and the prodomain of caspase-8 ( Mch5 / MACH / FLICE). CRADD / RAIDD has a dual-domain structure similar to that of FADD. CRADD / RAIDD has an NH2-terminal caspase homology domain that interacts with caspase-2 and a COOH-terminal DD that interacts with RIP. CRADD / RAIDD could play a role in regulating apoptosis in mammalian cells. CRADD / RAIDD is a apoptotic adaptor molecule specific for caspase-2 and FASL / TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD / RAIDD recruits caspase-2 to the TNFR-1 signalling complex.

    CRADD/RAIDD Alternative Name

    CRADD,MGC9163,RAIDD, [human]
    Cradd,RAIDD, [mouse]

    CRADD/RAIDD Related Studies

  • Ahmad,M. et al., 1997, Cancer Res. 57 (4):615-9.
  • Chou J.J., et al., 1998, Cell 94:171-80.
  • Tang,J. et al., 2005, Cancer Biol Ther. 4 (6):645-9.
  • Vakifahmetoglu H., et al., 2006, Oncogene 25:5683-92.
  • Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"