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> CRACC / SLAMF7 Protein & Antibody CRACC / SLAMF7 Protein & Antibody
CD2-like Receptor Activating Cytotoxic Cells / SLAM family member 7
CRACC / SLAMF7 Products
CRACC / SLAMF7 Protein, Recombinant
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| CRACC/SLAMF7 | Human | CRACC/SLAMF7 Protein, Recombinant |
11691-H08H |
| CRACC/SLAMF7 | Mouse | CRACC/SLAMF7 Protein, Recombinant |
50201-M08H |
11691-H08H: Measured by its ability to bind biotinylated human SLAMF7 in a functional ELISA.
50201-M08H: Measured by its ability to bind biotinylated mouse SLAMF7 in a functional ELISA.
CRACC / SLAMF7 Antibody
| Molecule | Application | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| Mouse CRACC/SLAMF7 |
WB, ELISA | CRACC/SLAMF7 Antibody, Rabbit MAb | 50201-R003 |
| Mouse CRACC/SLAMF7 |
WB, ELISA | CRACC/SLAMF7 Antibody, Rabbit MAb | 50201-R007 |
| Mouse CRACC/SLAMF7 |
WB, ELISA | Rabbit Polyclonal Antibody | 50201-RP01 |
| Mouse CRACC/SLAMF7 |
WB, ELISA | Rabbit Polyclonal Antibody (Antigen Affinity Purified) | 50201-RP02 |
CRACC / SLAMF7 cDNA Clone
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| CRACC/SLAMF7 | Human | Homo sapiens CRACC/SLAMF7 cDNA Clone | HG11691-G |
| CRACC/SLAMF7 | Mouse | Mus musculus CRACC/SLAMF7 cDNA Clone | MG50201-M |
CRACC / SLAMF7 Related Areas
Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>CRACC/SLAMF7
Immunology>>Innate Immunity>>Natural Killer Cell (NK Cell)>>CRACC/SLAMF7
Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>CRACC/SLAMF7/CD319
Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Macrophage Markers>>CRACC/SLAMF7/CD319
CRACC / SLAMF7 Alternative Names
CRACC, SLAMF7, CS1, 19A, CD319, [Homo sapiens]
CRACC, SLAMF7, CS1, 19A, 19A24, 4930560D03Rik [Mus musculus]
CRACC / SLAMF7 Related Products
Protein Products
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! |
| CD150/SLAM | Human | CD150/SLAM Protein, Recombinant |
| CD48/SLAMF2 | Human | CD48/SLAMF2 Protein, Recombinant |
| CD48/SLAMF2 | Mouse | CD48 Protein, Recombinant |
| Ly9/CD229/SLAMF3 | Mouse | LY9/CD229/SLAMF3 Protein, Recombinant |
| 2B4/CD244/SLAMF4 | Human | 2B4/CD244/SLAMF4/Fc Protein, Recombinant |
| 2B4/CD244/SLAMF4 | Human | 2B4/CD244/SLAMF4 Protein, Recombinant |
| CD84/SLAMF5 | Human | CD84/SLAMF5 Protein, Recombinant |
| Ly108/SLAMF6 | Human | Ly108/SLAMF6 Protein, Recombinant |
| Ly108/SLAMF6 | Mouse | Ly108/SLAMF6 Protein, Recombinant |
| SLAMF8 | Mouse | SLAMF8 Protein, Recombinant |
Antibody Products
cDNA Clone Products
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! |
| CD150/SLAM | Human | Homo sapiens CD150/SLAM cDNA Clone(NM_003037.2) |
| CD48/SLAMF2 | Human | Homo sapiens CD48/SLAMF2 cDNA Clone(NM_001778.2) |
| CD48/SLAMF2 | Mouse | Mus musculus CD48 cDNA Clone |
| Ly9/CD229/SLAMF3 | Mouse | Mus musculus LY9/CD229/SLAMF3 cDNA Clone |
| 2B4/CD244/SLAMF4 | Human | Homo sapiens 2B4/CD244/SLAMF4 cDNA Clone(NM_016382.2) |
| CD84/SLAMF5 | Human | Homo sapiens CD84/SLAMF5 cDNA Clone(NM_003874.2) |
| Ly108/SLAMF6 | Mouse | Mus musculus Ly108/SLAMF6 cDNA Clone |
| SLAMF8 | Human | Homo sapiens SLAMF8 cDNA Clone |
| SLAMF8 | Mouse | Mus musculus SLAMF8 cDNA Clone |
CRACC / SLAMF7 Background
SLAM family member 7 (SLAMF7), also known as CRACC, CD319, CD2-like receptor-activating cytotoxic cells, and CS1, is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruite signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/SH2D1A), it activates NK cells in the absence of a functional SAP. CS1 is a self ligand and homophilic interaction of CS1 regulates NK cell cytolytic activity. CRACC positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, CRACC can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.
CRACC / SLAMF7 Related Studies
- Lee JK, et al. (2004) Molecular and functional characterization of a CS1 (CRACC) splice variant expressed in human NK cells that does not contain immunoreceptor tyrosine-based switch motifs. Eur J Immunol. 34(10): 2791-9.
- Tassi I, et al. (2005) The cytotoxicity receptor CRACC (CS-1) recruits EAT-2 and activates the PI3K and phospholipase Cgamma signaling pathways in human NK cells. J Immunol. 175(12): 7996-8002.
- Lee JK, et al. (2007) CS1 (CRACC, CD319) induces proliferation and autocrine cytokine expression on human B lymphocytes. J Immunol. 179(7): 4672-8.
- Cruz-Munoz ME, et al. (2009) Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function. Nat Immunol. 10(3): 297-305.
