Anti-SLAMF7/CD319 Antibody

Cat: 50201-R007
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Anti-SLAMF7/CD319 Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-SLAMF7/CD319 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse SLAMF7/CD319
No cross-reactivity in ELISA with Human SLAMF7 / CRACC
Immunogen
Recombinant Mouse SLAMF7 protein (Catalog#50201-M08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse SLAMF7 extracellular domain (rM SLAMF7; Catalog#50201-M08H; NP_653122.2; Met 1-Gly 224).
Source
Monoclonal Rabbit IgG Clone #007
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-SLAMF7/CD319 Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-SLAMF7/CD319 Antibody Alternative Names
Anti-19A Antibody;Anti-19A24 Antibody;Anti-4930560D03Rik Antibody;Anti-CRACC Antibody;Anti-CS1 Antibody
SLAMF7/CD319 Background Information

SLAM family member 7 (SLAMF7), also known as CRACC, CD319, CD2-like receptor-activating cytotoxic cells, and CS1, is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruite signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/SH2D1A), it activates NK cells in the absence of a functional SAP. CS1 is a self ligand and homophilic interaction of CS1 regulates NK cell cytolytic activity. CRACC positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, CRACC can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.

Full Name
SLAM family member 7
References
  • Lee JK, et al. (2004) Molecular and functional characterization of a CS1 (CRACC) splice variant expressed in human NK cells that does not contain immunoreceptor tyrosine-based switch motifs. Eur J Immunol. 34(10): 2791-9.
  • Tassi I, et al. (2005) The cytotoxicity receptor CRACC (CS-1) recruits EAT-2 and activates the PI3K and phospholipase Cgamma signaling pathways in human NK cells. J Immunol. 175(12): 7996-8002.
  • Lee JK, et al. (2007) CS1 (CRACC, CD319) induces proliferation and autocrine cytokine expression on human B lymphocytes. J Immunol. 179(7): 4672-8.
  • Cruz-Munoz ME, et al. (2009) Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function. Nat Immunol. 10(3): 297-305.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-SLAMF7/CD319 Antibody Rabbit Polyclonal WB,ELISA 50201-RP02
    Anti-SLAMF7/CD319 Antibody Rabbit Polyclonal ELISA 50201-RP01
    Anti-SLAMF7/CD319 Antibody Rabbit Monoclonal ELISA 50201-R003
    Anti-SLAMF7/CD319 Antibody Rabbit Monoclonal ELISA 11691-R002
    Anti-SLAMF7/CD319 Antibody Rabbit Polyclonal ELISA 11691-RP01
    Anti-SLAMF7/CD319 Antibody Rabbit Polyclonal ELISA 11691-T16
    Anti-SLAMF7/CD319 Antibody Mouse Monoclonal ELISA 11691-MM02
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