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SLAMF7 / CRACC Antibody, Rabbit MAb

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    Mouse SLAMF7/CRACC Antibody Product Information
    Immunogen:Recombinant Mouse SLAMF7 protein (Catalog#50201-M08H)
    Clone ID:007
    Ig Type:Rabbit IgG
    Concentration:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Mouse SLAMF7 extracellular domain (rM SLAMF7; Catalog#50201-M08H; NP_653122.2; Met 1-Gly 224).
    Other SLAMF7/CRACC Antibody Products
    Reactivity: Human  
    Application: ELISA  
      11691-MM02-50
      11691-MM02-100
      11691-MM02-200
      50 µg 
      100 µg 
      200 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        11691-R002-50
        11691-R002-100
        50 µg 
        100 µg 
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        Reactivity: Human  
        Application: ELISA  
          11691-RP01-200
          11691-RP01-100
          11691-RP01-400
          200 µg 
          100 µg 
           
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          Reactivity: Mouse  
          Application: ELISA  
            50201-RP01-100
            50201-RP01-200
            100 µg 
            200 µg 
            Add to Cart
            Reactivity: Mouse  
            Application: ELISA  
              50201-RP02-50
              50201-RP02-100
              50 µg 
              100 µg 
              Add to Cart
              Reactivity: Mouse  
              Application: ELISA  
                50201-R003-50
                50201-R003-100
                50 µg 
                100 µg 
                Add to Cart
                Immunochemical staining of human CCNF in human brain with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
                CRACC/SLAM7/CD319 Background

                SLAM family member 7 (SLAMF7), also known as CRACC, CD319, CD2-like receptor-activating cytotoxic cells, and CS1, is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruite signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/SH2D1A), it activates NK cells in the absence of a functional SAP. CS1 is a self ligand and homophilic interaction of CS1 regulates NK cell cytolytic activity. CRACC positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, CRACC can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.

                Mouse CRACC/SLAM7/CD319 References
              • Lee JK, et al. (2004) Molecular and functional characterization of a CS1 (CRACC) splice variant expressed in human NK cells that does not contain immunoreceptor tyrosine-based switch motifs. Eur J Immunol. 34(10): 2791-9.
              • Tassi I, et al. (2005) The cytotoxicity receptor CRACC (CS-1) recruits EAT-2 and activates the PI3K and phospholipase Cgamma signaling pathways in human NK cells. J Immunol. 175(12): 7996-8002.
              • Lee JK, et al. (2007) CS1 (CRACC, CD319) induces proliferation and autocrine cytokine expression on human B lymphocytes. J Immunol. 179(7): 4672-8.
              • Cruz-Munoz ME, et al. (2009) Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function. Nat Immunol. 10(3): 297-305.
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                Catalog: 50201-R007-50
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                Datasheet & Documentation

                All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
                Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"