Anti-SLAMF7/CD319 Antibody

Cat: 50201-RP02
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All SLAMF7/CD319 Reagents
Anti-SLAMF7/CD319 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-SLAMF7/CD319 Antibody
Validated applications
Species reactivity
Reacts with: Mouse
Mouse SLAMF7/CD319
Recombinant Mouse SLAMF7 protein (Catalog#50201-M08H)
Produced in rabbits immunized with purified, recombinant Mouse SLAMF7 extracellular domain (rM SLAMF7; Catalog#50201-M08H; NP_653122.2; Met 1-Gly 224). SLAMF7 specific IgG was purified by mouse SLAMF7 affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-SLAMF7/CD319 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
WB 1:500-1:1000  
ELISA 1:25000-1:50000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-SLAMF7/CD319 Antibody (Rabbit Polyclonal antibody) Images
Mouse CRACC/SLAM7/CD319 Western blot (WB) 17400

Anti-SLAMF7 rabbit polyclonal antibody at 1:500 dilution

Lane A: 293T Whole Cell Lysate

Lysates/proteins at 30 μg per lane.


Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:37 kDa

Observed band size:45 kDa

Anti-SLAMF7/CD319 Antibody Alternative Names
Anti-19A Antibody;Anti-19A24 Antibody;Anti-4930560D03Rik Antibody;Anti-CRACC Antibody;Anti-CS1 Antibody
SLAMF7/CD319 Background Information

SLAM family member 7 (SLAMF7), also known as CRACC, CD319, CD2-like receptor-activating cytotoxic cells, and CS1, is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruite signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/SH2D1A), it activates NK cells in the absence of a functional SAP. CS1 is a self ligand and homophilic interaction of CS1 regulates NK cell cytolytic activity. CRACC positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, CRACC can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.

Full Name
SLAM family member 7
  • Lee JK, et al. (2004) Molecular and functional characterization of a CS1 (CRACC) splice variant expressed in human NK cells that does not contain immunoreceptor tyrosine-based switch motifs. Eur J Immunol. 34(10): 2791-9.
  • Tassi I, et al. (2005) The cytotoxicity receptor CRACC (CS-1) recruits EAT-2 and activates the PI3K and phospholipase Cgamma signaling pathways in human NK cells. J Immunol. 175(12): 7996-8002.
  • Lee JK, et al. (2007) CS1 (CRACC, CD319) induces proliferation and autocrine cytokine expression on human B lymphocytes. J Immunol. 179(7): 4672-8.
  • Cruz-Munoz ME, et al. (2009) Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function. Nat Immunol. 10(3): 297-305.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-SLAMF7/CD319 Antibody Rabbit Polyclonal ELISA 50201-RP01
    Anti-SLAMF7/CD319 Antibody Rabbit Monoclonal ELISA 50201-R007
    Anti-SLAMF7/CD319 Antibody Rabbit Monoclonal ELISA 50201-R003
    Anti-SLAMF7/CD319 Antibody Rabbit Monoclonal ELISA 11691-R002
    Anti-SLAMF7/CD319 Antibody Rabbit Polyclonal ELISA 11691-RP01
    Anti-SLAMF7/CD319 Antibody Rabbit Polyclonal ELISA 11691-T16
    Anti-SLAMF7/CD319 Antibody Mouse Monoclonal ELISA 11691-MM02
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