Anti-SLAMF7/CD319 Antibody (PE)

Cat: 50201-R052-P
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Anti-SLAMF7/CD319 Antibody (PE) (Rabbit Monoclonal antibody) General Information
Product name
Anti-SLAMF7/CD319 Antibody (PE)
Validated applications
FCM
Species reactivity
Reacts with: Mouse
Specificity
Mouse SLAMF7/CD319
Immunogen
Recombinant Mouse CRACC / SLAMF7 protein (Catalog#50201-M08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CRACC / SLAMF7 (rM CRACC / SLAMF7; Catalog#50201-M08H; NP_653122.2; Met1-Gly224) and conjugated with PE under optimum conditions, the unreacted PE was removed.
Source
Monoclonal Rabbit IgG Clone #052
Purification
Protein A
Formulation
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Conjugate
PE
Concentration
10 μl/Test, 0.1 mg/ml
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Anti-SLAMF7/CD319 Antibody (PE) (Rabbit Monoclonal antibody) Validated Applications

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-SLAMF7/CD319 Antibody (PE) (Rabbit Monoclonal antibody) Images
Mouse CRACC/SLAM7/CD319 Flow Cytometry (FC) 5539
Analysis of SLAMF7 (CD319) expression on spleen lymphocytes.
Anti-SLAMF7/CD319 Antibody (PE) Alternative Names
Anti-19A Antibody;Anti-19A24 Antibody;Anti-4930560D03Rik Antibody;Anti-CRACC Antibody;Anti-CS1 Antibody
SLAMF7/CD319 Background Information

SLAM family member 7 (SLAMF7), also known as CRACC, CD319, CD2-like receptor-activating cytotoxic cells, and CS1, is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruite signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/SH2D1A), it activates NK cells in the absence of a functional SAP. CS1 is a self ligand and homophilic interaction of CS1 regulates NK cell cytolytic activity. CRACC positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, CRACC can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.

Full Name
SLAM family member 7
References
  • Lee JK, et al. (2004) Molecular and functional characterization of a CS1 (CRACC) splice variant expressed in human NK cells that does not contain immunoreceptor tyrosine-based switch motifs. Eur J Immunol. 34(10): 2791-9.
  • Tassi I, et al. (2005) The cytotoxicity receptor CRACC (CS-1) recruits EAT-2 and activates the PI3K and phospholipase Cgamma signaling pathways in human NK cells. J Immunol. 175(12): 7996-8002.
  • Lee JK, et al. (2007) CS1 (CRACC, CD319) induces proliferation and autocrine cytokine expression on human B lymphocytes. J Immunol. 179(7): 4672-8.
  • Cruz-Munoz ME, et al. (2009) Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function. Nat Immunol. 10(3): 297-305.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-SLAMF7/CD319 Antibody Rabbit Polyclonal WB,ELISA 50201-RP02
    Anti-SLAMF7/CD319 Antibody Rabbit Polyclonal ELISA 50201-RP01
    Anti-SLAMF7/CD319 Antibody Rabbit Monoclonal ELISA 50201-R003
    Anti-SLAMF7/CD319 Antibody Rabbit Monoclonal ELISA 50201-R007
    Anti-SLAMF7/CD319 Antibody Rabbit Monoclonal ELISA 11691-R002
    Anti-SLAMF7/CD319 Antibody Rabbit Polyclonal ELISA 11691-RP01
    Anti-SLAMF7/CD319 Antibody Rabbit Polyclonal ELISA 11691-T16
    Anti-SLAMF7/CD319 Antibody Mouse Monoclonal ELISA 11691-MM02
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