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SLAMF7 / CRACC Antibody, Rabbit PAb

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Mouse SLAMF7/CRACC Antibody Product Information
Immunogen:Recombinant Mouse SLAMF7 protein (Catalog#50201-M08H)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Mouse SLAMF7 extracellular domain (rM SLAMF7; Catalog#50201-M08H; NP_653122.2; Met 1-Gly 224). Total IgG was purified by Protein A affinity chromatography.
Mouse SLAMF7/CRACC Antibody Usage Guide
Specificity:Mouse SLAMF7 / CRACC
Application:ELISA

ELISA: 0.5-1.0 μg/mL

This antibody can be used at 0.5-1.0 μg/mL with the appropriate secondary reagents to detect Mouse SLAMF7. The detection limit for Mouse SLAMF7 is 0.0195 ng/well.

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Other SLAMF7/CRACC Antibody Products
Reactivity: Human  
Application: ELISA  
    11691-MM02-50
    11691-MM02-100
    11691-MM02-200
    50 µg 
    100 µg 
    200 µg 
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    Reactivity: Human  
    Application: ELISA  
      11691-R002-50
      11691-R002-100
      50 µg 
      100 µg 
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      Reactivity: Human  
      Application: ELISA  
        11691-RP01-200
        11691-RP01-100
        11691-RP01-400
        200 µg 
        100 µg 
         
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        Reactivity: Mouse  
        Application: ELISA  
          50201-RP02-50
          50201-RP02-100
          50 µg 
          100 µg 
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          Reactivity: Mouse  
          Application: ELISA  
            50201-R003-50
            50201-R003-100
            50 µg 
            100 µg 
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            Reactivity: Mouse  
            Application: ELISA  
              50201-R007-50
              50201-R007-100
              50 µg 
              100 µg 
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              CRACC/SLAM7/CD319 Background

              SLAM family member 7 (SLAMF7), also known as CRACC, CD319, CD2-like receptor-activating cytotoxic cells, and CS1, is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruite signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/SH2D1A), it activates NK cells in the absence of a functional SAP. CS1 is a self ligand and homophilic interaction of CS1 regulates NK cell cytolytic activity. CRACC positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, CRACC can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.

              Mouse CRACC/SLAM7/CD319 References
            • Lee JK, et al. (2004) Molecular and functional characterization of a CS1 (CRACC) splice variant expressed in human NK cells that does not contain immunoreceptor tyrosine-based switch motifs. Eur J Immunol. 34(10): 2791-9.
            • Tassi I, et al. (2005) The cytotoxicity receptor CRACC (CS-1) recruits EAT-2 and activates the PI3K and phospholipase Cgamma signaling pathways in human NK cells. J Immunol. 175(12): 7996-8002.
            • Lee JK, et al. (2007) CS1 (CRACC, CD319) induces proliferation and autocrine cytokine expression on human B lymphocytes. J Immunol. 179(7): 4672-8.
            • Cruz-Munoz ME, et al. (2009) Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function. Nat Immunol. 10(3): 297-305.
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              Catalog: 50201-RP01-400
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              All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
              Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"