Anti-CRABP2 Antibody

Cat: 11203-RP01
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Anti-CRABP2 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-CRABP2 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human CRABP2
Immunogen
Recombinant Human CRABP2 protein (Catalog#11203-H07E)
Preparation
Produced in rabbits immunized with purified, recombinant Human CRABP2 (rh CRABP2; Catalog#11203-H07E; NP_001869.1; Pro2-Glu 138). Total IgG was purified by Protein A affinity chromatography .
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CRABP2 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CRABP2 Antibody Alternative Names
Anti-CRABP-II Antibody;Anti-RBP6 Antibody
CRABP2 Background Information

Cellular retinoic acid-binding protein 2, also known as Cellular retinoic acid-binding protein II, CRABP-II and CRABP2, is a protein which belongs to the calycin superfamily and Fatty-acid binding protein (FABP) family. Cellular retinoic acid binding proteins (CRABP) are low molecular weight proteins whose precise function remains unknown. The predicted amino acid sequences of human CRABP1 and CRABP2 demonstrated a 99.3% and 93.5% identity to mouse CRABP1 and CRABP2, respectively. CRABP2 forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. Expression of CRABP2, but not CRABP1 mRNA, was markedly increased (greater than 15-fold) by retinoic acid treatment of fibroblasts cultured from human skin, whereas no significant induction of CRABP2 mRNA was observed in human lung fibroblasts. CRABP2 transports retinoic acid to the nucleus. It regulates the access of retinoic acid to the nuclear retinoic acid receptors. CRABP2 is necessary for elastin induction by All-trans retinoic acid (ATRA) in MRC-5 cells. It is expressed at low levels in emphysema fibroblasts. This alteration in the retinoic acid signalling pathway in lung fibroblasts may contribute to the defect of alveolar repair in human pulmonary emphysema.

Full Name
cellular retinoic acid binding protein 2
References
  • Deak,KL.et al., 2005,Birth Defects Res A Clin Mol Teratol.73 (11): 868-75.
  • Plantier, L. et al., 2008, Thorax  63 (11): 1012-7.
  • Calmon, M.F. et al., 2009, Neoplasia  11 (12): 1329-39.
  • Welch, I.D. et al., 2009, Arthritis Res Ther  11 (1): R14.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CRABP2 Antibody Rabbit Polyclonal WB,ELISA,IHC-P 50535-RP02
    Anti-CRABP2 Antibody Rabbit Monoclonal ELISA 50535-R101
    Anti-CRABP2 Antibody Rabbit Polyclonal ELISA 50535-RP01
    Anti-CRABP2 Antibody Mouse Monoclonal FCM,ICC/IF,IF 11203-MM05
    Anti-CRABP2 Antibody (PE) Rabbit Monoclonal FCM 11203-R004-P
    Anti-CRABP2 Antibody Rabbit Polyclonal WB,ELISA,IP 11203-RP02
    Anti-CRABP2 Antibody Mouse Monoclonal IHC-P 11203-MM01
    Anti-CRABP2 Antibody Mouse Monoclonal WB,ELISA 11203-MM04
    Anti-CRABP2 Antibody Rabbit Monoclonal WB,FCM,ICC/IF,IF,IP 11203-R004
    Anti-CRABP2 Antibody (FITC) Rabbit Monoclonal FCM 11203-R004-F
    Anti-CRABP2 Antibody (FITC) Mouse Monoclonal FCM 11203-MM05-F
    Anti-CRABP2 Antibody (PE) Mouse Monoclonal FCM 11203-MM05-P
    Anti-CRABP2 Antibody Rabbit Monoclonal WB 11203-R016
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