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COX-2/PTGS2 Protein, Antibody, ELISA Kit, cDNA Clone

COX-2/PTGS2 Related Areas

COX-2/PTGS2 Related Pathways

COX-2/PTGS2 Related Product

    COX-2/PTGS2 Summary & Protein Information

    COX-2/PTGS2 Background

    Gene Summary: Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. PTGS2 gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009]
    General information above from NCBI
    Catalytic activity: Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O.
    Cofactor: Binds 1 heme B (iron-protoporphyrin IX) group per subunit (By similarity).
    Subunit structure: Homodimer (By similarity).
    Subcellular location: Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
    Induction: By cytokines and mitogens.
    Post-translational: S-nitrosylation by NOS2 (iNOS) activates enzyme activity. S- nitrosylation may take place on different Cys residues in addition to Cys-561.
    Sequence similarity: Belongs to the prostaglandin G/H synthase family.
    Contains 1 EGF-like domain.
    General information above from UniProt

    PTGS2, also known as COX-2, is s component of Prostaglandin-endoperoxide synthase (PTGS). PTGS, also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. PTGS2 is over expressed in many cancers. The overexpression of PTGS2 along with increased angiogenesis and GLUT-1 expression is significantly associated with gallbladder carcinomas. Furthermore the product of COX-2, PGH2 is converted by prostaglandin E2 synthase into PGE2, which in turn can stimulate cancer progression. Consequently inhibiting COX-2 may have benefit in the prevention and treatment of these types of cancer. PTGS2 is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. It mediates the formation of prostaglandins from arachidonate and may have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.

    COX-2/PTGS2 Alternative Name

    PTGS2,COX2,COX-2,GRIPGHS,hCox-2,PGG/HS,PGHS-2,PHS-2, [human]
    TIS10,COX2,Cox-2,Pghs2,PGHS-2,PHS-2,Ptgs2, [mouse]

    COX-2/PTGS2 Related Studies

  • Picot, et al. (1994) The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1. Nature. 367(6460):243-9.
  • Xie W, et al. (1991) Expression of a Mitogen-Responsive Gene Encoding Prostaglandin Synthase is Regulated by mRNA Splicing. Proceedings of the National Academy of Sciences. 88(7):2692-6.
  • Hla T, et al. (1992) Human Cyclooxygenase-2 cDNA. Proceedings of the National Academy of Sciences. 89(16):7384-8.
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