COX-2 / PTGS2 Protein

Cyclooxygenase-2 / Prostaglandin-endoperoxide synthase 2

COX-2 / PTGS2 Products

COX-2 / PTGS2 Protein, Recombinant

Molecule	Species	Description	Cat. No
COX-2/PTGS2	Human	COX-2/PGHS2 Protein, Recombinant	12036-H08B

COX-2 / PTGS2 cDNA Clone

Molecule	Species	Description	Cat. No
COX-2/PTGS2	Human	Homo sapiens COX-2/PGHS2 cDNA Clone	HG12036-G

COX-2 / PTGS2 Related Areas

Enzyme>>Other>>COX-2/PTGS2

COX-2 / PTGS2 Alternative Names

COX-2, PTGS2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 [Homo sapiens]

Cox-2, Ptgs2, COX2, PGHS-2, PHS-2, Pghs2, TIS10 [Mus musculus]

COX-2 / PTGS2 Background

PTGS2, also known as COX-2, is s component of Prostaglandin-endoperoxide synthase (PTGS). PTGS, also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. PTGS2 is over expressed in many cancers. The overexpression of PTGS2 along with increased angiogenesis and GLUT-1 expression is significantly associated with gallbladder carcinomas. Furthermore the product of COX-2, PGH2 is converted by prostaglandin E2 synthase into PGE2, which in turn can stimulate cancer progression. Consequently inhibiting COX-2 may have benefit in the prevention and treatment of these types of cancer. PTGS2 is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. It mediates the formation of prostaglandins from arachidonate and may have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.

COX-2 / PTGS2 Related Studies

1. Picot, et al. (1994) The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1. Nature. 367(6460):243-9.
2. Xie W, et al. (1991) Expression of a Mitogen-Responsive Gene Encoding Prostaglandin Synthase is Regulated by mRNA Splicing. Proceedings of the National Academy of Sciences. 88(7):2692-6.
3. Hla T, et al. (1992) Human Cyclooxygenase-2 cDNA. Proceedings of the National Academy of Sciences. 89(16):7384-8.