+86-400-890-9989
Product Catalog
> COQ7 COQ7
COQ7 is involved in lifespan determination in ubiquinone-independent manner. COQ7 is involved in ubiquinone biosynthesis. Potential central metabolic regulator.
- Research Tools:
Protein, cDNA Clone,
Antibody, ELISA Kit - All Produced in House
- Quality Guarantee
- Bulk Order
- Cost Saving
- Products (protein, antibody, ELISA kit, cDNA clone)
- Related Areas (research topics)
- Pathways
- Alternative Names
- Summaries
- Protein General Information
(domain, location, disease, etc) - Function
- Homology
- Phenotype (disorder & disease)
- Drugs
- Hot Molecules
COQ7 Related Products
COQ7 Proteins
COQ7 Antibodies
- Anti-Human COQ7 Antibody, Rabbit PAb (Antigen Affinity Purified), Cat NO: 12195-RP02
- Anti-Human COQ7 Antibody, Cat NO: 12195-MM05
COQ7 ELISA Pair sets
COQ7 cDNA Clones
- Human COQ7 cDNA Clone / ORF Clone, Cat NO: HG12195-G
- Mouse COQ7 cDNA Clone / ORF Clone, Cat NO: MG50969-G
COQ7 Related Areas
COQ7 Related Pathways
COQ7 Alternative Names
COQ7, CAT5, CLK-1, CLK1 [Homo sapiens]
Coq7, clk-1 [Mus musculus]
Summaries for COQ7
Entrez Gene summary for COQ7:
The protein encoded by this COQ7 gene is similar to a mitochondrial di-iron containing hydroxylase in Saccharomyces cerevisiae that is involved with ubiquinone biosynthesis. Mutations in the yeast gene lead to slower development and longer life span. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]
Wikipedia summary for COQ7:
The CLK1 (Clock abnormal protein 1) gene encodes an enzyme (demethoxyubiquinone mono-oxygenase) that is necessary for ubiquinone biosynthesis in the worm C. elegans and other eukaryotes. The mouse version of the gene is called mclk1 and the human, fruit fly and yeast homolog COQ7 (Coenzyme Q biosynthesis protein 7 homolog).
COQ7 is not to be confused with the unrelated CLK1 human gene which plays a role in RNA splicing.
Human COQ7 Protein General Information
| Protein names |
Coenzyme Q biosynthesis protein 7 homolog |
| Sequence length |
217 AA. |
| Sequence similarities: |
COQ7 belongs to the COQ7 family. |
| Cofactor: |
COQ7 binds 2 iron ions per subunit |
| Pathway |
Cofactor biosynthesis; ubiquinone biosynthesis. |
| Subcellular location: | Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Note: Synthesized as a preprotein that is imported into the mitochondrial matrix, where the sequence is cleaved off and the mature protein becomes loosely associated with the inner membrane |
| Tissue specificity |
COQ7 is expressed dominantly in heart and skeletal muscle. |
General information above from UniProt
Function for COQ7 Protein
UniProtKB:
COQ7 is involved in lifespan determination in ubiquinone-independent manner. COQ7 is involved in ubiquinone biosynthesis. Potential central metabolic regulator.
Genatlas:
- COQ7 catalyzes the production of coenzyme Q (CoQ) in mitochondria
- COQ7 is involved in ubiquinone biosynthesis and hence, is required for respiration and gluconeogenesis
- COQ7 functions as a hydroxylase
Homology for human COQ7
- homolog to yeast S.cerevisiae cat5p
- homolog to C.elegans longevity gene clk1
