Anti-COQ7 Antibody

Cat: 12195-MM05
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All COQ7 Reagents
Anti-COQ7 Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-COQ7 Antibody
Validated applications
WB
Species reactivity
Reacts with: Human
Specificity
Human COQ7
Has cross-reactivity in ELISA with Human COQ7 in 293 cell lysate
Immunogen
Recombinant Human COQ7 protein (Catalog#12195-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human COQ7 (rh COQ7; Catalog#12195-H08H; Q99807-1; Ser 37-Leu 217). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG1 Clone #7C7C7
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-COQ7 Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
WB 1:500-1:1000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-COQ7 Antibody (Mouse Monoclonal antibody) Images
Human COQ7 Western blot (WB) 16055

Anti-COQ7 mouse monoclonal antibody at 1:500 dilution

Lane A: HL-60 Whole Cell Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti-Mouse IgG H&L (Dylight800) at 1/15000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:24 kDa

Observed band size:24 kDa

Anti-COQ7 Antibody Alternative Names
Anti-CAT5 Antibody;Anti-CLK-1 Antibody;Anti-CLK1 Antibody
COQ7 Background Information

Ubiquinone biosynthesis protein COQ7 homolog, also known as Coenzyme Q biosynthesis protein 7 homolog, Timing protein clk-1 homolog and COQ7, is a mitochondrion inner membrane and peripheral membrane protein which belongs to the COQ7 family. It is expressed dominantly in heart and skeletal muscle. COQ7 is synthesized as a preprotein that is imported into the mitochondrial matrix, where the sequence is cleaved off and the mature protein becomes loosely associated with the inner membrane. This enzyme is responsible for the hydroxylation of 5-demethoxyubiquinone to 5-hydroxyubiquinone. Human COQ7 protein is mostly helical, and contains an alpha-helical membrane insertion. It has a potential N-glycosylation site, a phosphorylation site for protein kinase C and another for casein kinase II, and three N-myristoylation sites. COQ7 is involved in lifespan determination in ubiquinone-independent manner. It is also involved in ubiquinone biosynthesis. COQ7 is potential central metabolic regulator.

Full Name
coenzyme Q7 homolog, ubiquinone (yeast)
References
  • Ewbank J.J., et al., 1997, Science. 275: 980-3.
  • Vajo Z., et al., 1999, Mamm. Genome. 10: 1000-4.
  • Wiemann S., et al., 2001, Genome Res. 11: 422-35.
  • Stenmark,P. et al., 2001, J Biol Chem. 276 (36): 33297-300.
  • Martin J., et al., 2004, Nature. 432: 988-94. 
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-COQ7 Antibody Rabbit Polyclonal ELISA 12195-T16
    Anti-COQ7 Antibody Rabbit Polyclonal ELISA 12195-T16
    Anti-COQ7 Antibody Rabbit Polyclonal ELISA 12195-RP02
    Anti-COQ7 Antibody Mouse Monoclonal ELISA 12195-MM01
    Anti-COQ7 Antibody Mouse Monoclonal ELISA(Cap) 12195-MM06
    Anti-COQ7 Antibody Rabbit Polyclonal ELISA 12195-RP01
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