COMP Protein & Antibody (Thrombospondin-5)

Cartilage Oligomeric Matrix Protein

COMP Products

COMP Protein, Recombinant

Molecule	Species	Description	Cat. No
COMP/Thrombospondin-5	Human	COMP/Thrombospondin-5 Protein, Recombinant	10173-H08H

COMP Antibody

Molecule	Application	Description	Cat. No
Human COMP/Thrombospondin-5	WB, ELISA	Mouse Monoclonal Antibody	10173-MM02
Human COMP/Thrombospondin-5	ELISA	Rabbit Polyclonal Antibody	10173-RP01
Human COMP/Thrombospondin-5	ELISA	Rabbit Polyclonal Antibody(Antigen Affinity Purified)	10173-RP03

COMP/Thrombospondin-5 ELISA Kit

Molecule	Application	Description	Cat. No
Human COMP/Thrombospondin-5	ELISA	COMP/Thrombospondin-5 ELISA Kit	SEK10173

COMP cDNA Clone

Molecule	Species	Description	Cat. No
COMP/Thrombospondin-5	Human	Homo sapiens COMP/Thrombospondin-5 cDNA Clone(NM_000095.2)	HG10173-M

COMP Related Areas

Immunology>>Adhesion Molecule>>Extracellular Matrix Molecule>>Extracellular Matrix Protein>>Transglutaminase-5/COMP

COMP Alternative Names

COMP, thrombospondin-5, THBS5, EDM1, EPD1, MED, MGC131819, MGC149768, PSACH [Homo sapiens]

Comp, thrombospondin-5, TSP5 [Mus musculus]

COMP Background

Cartilage Oligomeric Matrix Protein (COMP), also referred to as Thrombospondin-5, is a non-collagenous extracellular matrix (ECM) protein and belongs to the subgroup B of the thrombospondin protein family. This protein is expressed primarily in cartilage, ligament, and tendon, and binds to other ECM proteins such as collagen I, II and IX with high affinities depending on the divalent cations Zn2+ or Ni2+. COMP is a secreted glycoprotein that is important for growth plate organization and function. It is suggested to play a role in cell growth and development, and recent studies have revealed the possible mechanism that it protects cells against death by elevating members of the IAP (inhibitor of apoptosis protein) family of survival proteins. Mutations in COMP cause two skeletal dysplasias, pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (EDM1), and up-regulated expression of COMP are observed in rheumatoid arthritis and certain carcinomas.

COMP Related Studies

1. Posey KL, et al. (2004) Role of TSP-5/COMP in pseudoachondroplasia. Int J Biochem Cell Biol. 36(6): 1005-12.
2. Chen FH, et al. (2005) Interaction of cartilage oligomeric matrix protein/thrombospondin 5 with aggrecan. J Biol Chem. 282(34): 24591-8.
3. Posey KL, et al. (2008) The role of cartilage oligomeric matrix protein (COMP) in skeletal disease. Curr Drug Targets. 9(10): 869-77.
4. Tan K, et al. (2009) The crystal structure of the signature domain of cartilage oligomeric matrix protein: implications for collagen, glycosaminoglycan and integrin binding. FASEB J. 23(8): 2490-501.