All COMP reagents are produced in house and quality controlled, including 3 COMP Antibody, 2 COMP ELISA, 13 COMP Gene, 1 COMP Lysate, 1 COMP Protein, 1 COMP qPCR. All COMP reagents are ready to use.
Recombinant COMP proteins are expressed by HEK293 Cells with fusion tags as C-His.
COMPantibodies are validated with different applications, which are ELISA, ELISA(Cap).
COMPcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each COMP of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
COMPELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
Cartilage Oligomeric Matrix Protein (COMP), also referred to as Thrombospondin-5, is a non-collagenous extracellular matrix (ECM) protein and belongs to the subgroup B of the thrombospondin protein family. This protein is expressed primarily in cartilage, ligament, and tendon, and binds to other ECM proteins such as collagen I, II and IX with high affinities depending on the divalent cations Zn2+ or Ni2+. COMP is a secreted glycoprotein that is important for growth plate organization and function. It is suggested to play a role in cell growth and development, and recent studies have revealed the possible mechanism that it protects cells against death by elevating members of the IAP (inhibitor of apoptosis protein) family of survival proteins. Mutations in COMP cause two skeletal dysplasias, pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (EDM1), and up-regulated expression of COMP are observed in rheumatoid arthritis and certain carcinomas.