All COL4A3 reagents are produced in house and quality controlled, including 1 COL4A3 Lysate, 1 COL4A3 Protein. All COL4A3 reagents are ready to use.
Recombinant COL4A3 proteins are expressed by HEK293 Cells with fusion tags as N-human IgG1-Fc.
COL4A3 is a major structural component of basement membranes. It is composed of 3 alpha subunits, which are encoded by 6 different genes, alpha 1 through alpha 6. Each of these alpha subunits can form a triple helix structure with 2 other subunits to form COL4A3. Autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli can cause goodpasture syndrome. COL4A3 is also linked to an autosomal recessive form of alport syndrome. COL4A3 is organized in a head-to-head conformation and each gene pair shares a common promoter.