CNTNAP2 / CASPR2 Protein & Antibody

Contactin associated protein-like 2 / Contactin-associated protein 2

CNTNAP2 / CASPR2 Products

CNTNAP2 / CASPR2 Protein, Recombinant

Molecule	Species	Description	Cat. No
CNTNAP2/CASPR2	Mouse	CNTNAP2/CASPR2 Protein, Recombinant	50649-M08H

  50649-M08H: Mouse CASPR2 immobilized at 0.8 µg/mL, 100 µL/well will mediate > 30 % C6 cell adhesion. Measured by the ability of the immobilized protein to support the adhesionof C6 Rat brain glial cells.

CNTNAP2 / CASPR2 Antibody

Molecule	Application	Description	Cat. No
Mouse CNTNAP2/CASPR2	WB, ELISA	CNTNAP2 / CASPR2 Antibody	50649-RP01
Mouse CNTNAP2/CASPR2	WB, ELISA	CNTNAP2 / CASPR2 Antibody (Antigen Affinity Purified)	50649-RP02

CNTNAP2 / CASPR2 Related Areas

Immunology>>Adhesion Molecule>>Cell Adhesion Molecule (IgSF CAM)>>CNTNAP2/CASPR2

CNTNAP2 / CASPR2 Alternative Names

CNTNAP2, CASPR2, AUTS15, CDFE, DKFZp781D1846, NRXN4, PTHSL1 [Homo sapiens]

Cntnap2, Caspr2, 5430425M22Rik, mKIAA0868 [Mus musculus]

CNTNAP2 / CASPR2 Background

CNTNAP2/CASPR2 is a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. CNTNAP2/CASPR2 is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This protein encoding gene is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation. CNTNAP2/CASPR2 may play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. CNTNAP2/CASPR2 Seems to demarcate the juxtaparanodal region of the axo-glial junction.

CNTNAP2 / CASPR2 Related Studies

1. Poot M, et al. (2010) Disruption of CNTNAP2 and additional structural genome changes in a boy with speech delay and autism spectrum disorder. Neurogenetics. 11(1): 81-9.
2. Friedman JI, et al. (2008) CNTNAP2 gene dosage variation is associated with schizophrenia and epilepsy. Mol Psychiatry. 13(3): 261-6.
3. Verkerk AJ, et al. (2003) CNTNAP2 is disrupted in a family with Gilles de la Tourette syndrome and obsessive compulsive disorder. Genomics. 82(1): 1-9.