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CNTNAP2 / CASPR2 Antibody, Rabbit MAb
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CNTNAP2 / CASPR2 Antibody, Rabbit MAb PDF Download

Catalog   Size (Price) Quantity In Stock Operation
50649-R001  

YES   
 

Primary antibody | Secondary antibody | Tag antibody | Isotype control antibody | Loading control antibody | Antibody Purification

CNTNAP2 / CASPR2 Antibody Datasheet

  Order or Inquire for CNTNAP2 / CASPR2 Antibody product Quality antibodies Antibody production services
  Detection limit is 0.0195 ng/well in ELISA
 

CNTNAP2 / CASPR2 Antibody Product Information

Immunogen :

Recombinant Mouse CNTNAP2 / CASPR2 protein (Catalog#50649-M08H)

Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )

Clone ID :

001

Ig Type :

Rabbit IgG

Formulation : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
Preparation :

This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CNTNAP2 / CASPR2 (rM CNTNAP2 / CASPR2; Catalog#50649-M08H; NP_001004357.2; Met 1-Ser 1262).

CNTNAP2 / CASPR2 Antibody Usage Guide

Specificity :

Mouse CNTNAP2 / CASPR2

Direct ELISA : This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse CASPR2. The detection limit for Mouse CASPR2 is approximately 0.0195 ng/well.
Storage : This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

CNTNAP2 / CASPR2 Antibody Related Products & Topics

Related Areas:

Proteins:

Antibodies:

CNTNAP2 / CASPR2 Antibody Background

Contactin-associated protein-like 2, also known as Cell recognition molecule Caspr2, CNTNAP2 and CASPR2, is a single-pass type I membrane protein which belongs to the neurexin family. CNTNAP2 contains two EGF-like domains, one F5/8 type C domain, one fibrinogen C-terminal domain, fourlaminin G-like domains. Defects in CNTNAP2 are the cause of cortical dysplasia-focal epilepsy syndrome (CDFES). Affected individuals manifest cortical dysplasia, focal epilepsy, relative macrocephaly, and diminished deep-tendon reflexes. Intractable focal seizures begin in early childhood, after which language regression, hyperactivity, impulsive and aggressive behavior, and mental retardation develop. Genetic variations in CNTNAP2 influences susceptibility to autism type 15 which is a neurodevelopmental disorder characterized by disturbance in language, perception and socialization. The disorder is classically defined by a triad of limited or absent verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted, stereotypical, and ritualized patterns of interests and behavior.

References

  1. Verkerk, A.J. et al., 2003, Genomics. 82 (1): 1-9.
  2. Arking, DE. et al., 2008,Am J Hum Genet. 82 (1): 160-4.
  3. Zweier,C. et al., 2009,Am J Hum Genet85 (5): 655-66. 4. Tan,G.C. et al., 2010,Neuroimage. 53 (3): 1030-42.
 
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"