CNTNAP2 / CASPR2 Antibody

CNTNAP2 / CASPR2 Antibody Datasheet

CNTNAP2 / CASPR2 Antibody Product Information

• Immunogen: Recombinant Mouse CNTNAP2 / CASPR2 protein (Catalog#50649-M08H)
• Antibody Type: Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
• Clone ID: 001
• Ig Type: Rabbit IgG
• Formulation: 0.2 μm filtered solution in PBS with 5% trehalose
• Preparation: This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CNTNAP2 / CASPR2 (rM CNTNAP2 / CASPR2; Catalog#50649-M08H; NP_001004357.2; Met 1-Ser 1262).

CNTNAP2 / CASPR2 Antibody Usage Guide

• Specificity: Mouse CNTNAP2 / CASPR2
• Direct ELISA: This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse CASPR2. The detection limit for Mouse CASPR2 is approximately 0.0195 ng/well.
• Storage: This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
  Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

CNTNAP2 / CASPR2 Antibody Background

Contactin-associated protein-like 2, also known as Cell recognition molecule Caspr2, CNTNAP2 and CASPR2, is a single-pass type I membrane protein which belongs to the neurexin family. CNTNAP2 contains two EGF-like domains, one F5/8 type C domain, one fibrinogen C-terminal domain, fourlaminin G-like domains. Defects in CNTNAP2 are the cause of cortical dysplasia-focal epilepsy syndrome (CDFES). Affected individuals manifest cortical dysplasia, focal epilepsy, relative macrocephaly, and diminished deep-tendon reflexes. Intractable focal seizures begin in early childhood, after which language regression, hyperactivity, impulsive and aggressive behavior, and mental retardation develop. Genetic variations in CNTNAP2 influences susceptibility to autism type 15 which is a neurodevelopmental disorder characterized by disturbance in language, perception and socialization. The disorder is classically defined by a triad of limited or absent verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted, stereotypical, and ritualized patterns of interests and behavior.

References

1. Verkerk, A.J. et al., 2003, Genomics. 82 (1): 1-9.
2. Arking, DE. et al., 2008,Am J Hum Genet. 82 (1): 160-4.
3. Zweier,C. et al., 2009,Am J Hum Genet85 (5): 655-66. 4. Tan,G.C. et al., 2010,Neuroimage. 53 (3): 1030-42.