CNTFR Protein & Antibody

 

CNTFR Products

CNTFR Protein, Recombinant

Molecule	Species	Description	Cat. No
CNTFR	Human	CNTFR / CNTFR-alpha Protein, Recombinant	11012-H08B
CNTFR	Rat	CNTFR / CNTFR-alpha Protein, Recombinant	80019-R08B

CNTFR Antibody

Molecule	Application	Description	Cat. No
Human CNTFR	WB, ELISA	CNTFR / CNTFR-alpha Antibody	11012-RP01
Human CNTFR	WB, ELISA	CNTFR / CNTFR-alpha Antibody (Antigen Affinity Purified)	11012-RP02
Rat CNTFR	WB, ELISA	CNTFR Antibody (Antigen Affinity Purified)	80019-RP02
Rat CNTFR	WB, ELISA	CNTFR Antibody	80019-MM06

CNTFR cDNA Clone

Molecule	Species	Description	Cat. No
CNTFR	Human	CNTFR cDNA Clone / ORF Clone	HG11012-M
CNTFR	Rat	CNTFR cDNA Clone / ORF Clone	RG80019-M

CNTFR Related Areas

Neuroscience>>Neurotrophic Factor & Receptor>>Other Neurotrophic Factors>>CNTFR

CNTFR Alternative Names

RP11-296L22.1, CNTF receptor subunit alpha, CNTFR-alpha [Homo sapiens]

CNTF receptor subunit alpha, CNTFR alpha, CNTFR-alpha, ciliary neurotrophic factor receptor alpha, ciliary neurotrophic factor receptor subunit alpha [Rattus norvegicus]

CNTFR Background

Ciliary neurotrophic factor(CNTF) is a member of the cytokine family. It is a polypeptide hormone that have functions in promoting neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. It's actions appear to be restricted to the nervous system. Ciliary neurotrophic factor(CNTF) has biological effects through the activation of a multi-subunit receptor complex, consisting of an extracelluar CNTF binding subunit(CNTFα) and two transmembrane signal transduction proteins: glycoprotein gp130 and LIF receptor. CNTF is considered as a potent survival factor of neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. CNTF is also a survival factor for neurons of the peripheral sensory sympathetic, and ciliary ganglia. It has been reported that CNTF could be an agent that has therapeutic potential and possibly induces differentiation of large multipolar ganglionic phenotype in a subset of progenitors.

CNTFR Related Studies

1. Dutt K, et al. (2010) Ciliary neurotrophic factor: a survival and differentiation inducer in human retinal progenitors. In Vitro Cell Dev Biol Anim. 46 (7) : 635-46.
2. Lam A, et al. ( 1991) Sequence and structural organization of the human gene encoding ciliary neurotrophic factor. Gene 102 (2) : 271-6.
3. Bazan JF. ( 1991) Neuropoietic cytokines in the hematopoietic fold. Neuron 7 (2) : 197-208.