CNTF Protein & Antibody

Ciliary Neurotrophic Factor

CNTF Products

CNTF Protein, Recombinant

Molecule	Species	Description	Cat. No
CNTF	Human	CNTF Protein, Recombinant	11841-H07E
CNTF	Rat	CNTF Protein, Recombinant, Native	80012-RNAE

  11841-H07E:

1. Immobilized human CTNFR at 10 µg/ml (100 µl/well) can bind biotinylated human CNTF with a linear ranger of 1.28-160 ng/ml. Measured by its binding ability in a functional ELISA.

2. Immobilized Rat CTNFR at 10 µg/ml (100 µl/well) can bind biotinylated human CNTF with a linear ranger of 1.28-160 ng/ml. Measured by its binding ability in a functional ELISA.

CNTF Antibody

Molecule	Application	Description	Cat. No
Human ASAM	ELISA	CNTF Antibody, Mouse Mab	11841-R001
Human ASAM	WB	CNTF Antibody, Mouse Mab	11841-R006
Human ASAM	WB, ELISA	CNTF Antibody, Rabbit Pab	11841-RP02
Rat ASAM	WB, ELISA	CNTF Antibody	80012-RP01
Rat ASAM	WB, ELISA	CNTF Antibody (Antigen Affinity Purified)	80012-RP02

CNTF cDNA Clone

Molecule	Species	Description	Cat. No
CNTF	Rat	Rattus norvegicus CNTF cDNA Clone	RG80012-M

CNTF Related Areas

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-6 Family & Receptor>>CNTF

Neuroscience>>Neurotrophic Factor & Receptor>>Other Neurotrophic Factors & Receptors>>CNTF

CNTF Alternative Names

CNTF, HCNTF [Homo sapiens]

Cntf, AI429687, MGC41235 [Mus musculus]

CNTF Background

Ciliary neurotrophic factor (CNTF) is a member of the cytokine family. It is a polypeptide hormone that have functions in promoting neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. It's actions appear to be restricted to the nervous system. Ciliary neurotrophic factor (CNTF) has biological effects through the activation of a multi- subunit receptor complex, consisting of an extracelluar CNTF binding subunit (CNTFα) and two transmembrane signal transduction proteins: glycoprotein gp130 and LIF receptor. CNTF is considered as a potent survival factor of neurons and oligodendrocyteands may be relevant in reducing tissue destruction during inflammatory attacks. CNTF also is a survival factor for neurons of the peripheral sensory sympathetic and ciliary ganglia. It has been reported that CNTF could be an agent that has therapeutic potential and possibly induces differentiation of large multipolar ganglionic phenotype in a subset of progenitors.

CNTF Related Studies

1. Dutt K, et al. (2010) Ciliary neurotrophic factor: a survival and differentiation inducer in human retinal progenitors. In Vitro Cell Dev Biol Anim. 46 (7) : 635-46.
2. Lam A, et al.(1991) Sequence and structural organization of the human gene encoding ciliary neurotrophic factor. Gene 102 (2) : 271–6.
3. Bazan JF. ( 1991) Neuropoietic cytokines in the hematopoietic fold. Neuron 7 (2) : 197–208.