CNPY4

CNPY4 belongs to the canopy family. CNPY4 interacts with toll-like receptor 4 (TLR4) and plays a role in the regulation of the cell surface expression of TLR4. Toll-like receptors (TLRs) recognize microbial products and induce immune responses. Lipopolysaccharide is recognized by the receptor complex consisting of TLR4 and MD-2. As CNPY4, PRAT4B also regulates cell surface expression of TLR4. PRAT4B has a signal peptide followed by a mature peptide. It is associated with the hypoglycosylated, immature form of TLR4 but not with MD-2 or TLR2.

CNPY4 Alternative Names

PSEC0237, PRAT4B, PRotein Associated with Tlr4, protein canopy homolog 4 [Homo sapiens]

2610019P18Rik, protein associated with Tlr4, protein canopy homolog 4 [Mus musculus]

Human CNPY4 Protein General Information

 

• Protein names: CNPY4
• Sequence length: 248 AA.
• Domain: Signal
• Sequence similarities: Belongs to the canopy family.
  Contains 1 saposin B-type domain.
• Subunit structure: Interacts with TLR4
• Subcellular location: Secreted

General information above from UniProt

Function for CNPY4 Protein

UniProtKB:

CNPY4 plays a role in the regulation of the cell surface expression of TLR4.

Genatlas:

• CNPY4 regulates cell surface expression of TLR4