Anti-CNDP2 Antibody

Cat: 50246-RP02
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Anti-CNDP2 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-CNDP2 Antibody
Validated applications
WB,ELISA,IP
Species reactivity
Reacts with: Mouse
Specificity
Mouse CNDP2
Immunogen
Recombinant Mouse CNDP2 protein (Catalog#50246-M08B)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse CNDP2 (rM CNDP2; Catalog#50246-M08B; NP_075638.2; Met 1-Asn 475). CNDP2 specific IgG was purified by Mouse CNDP2 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CNDP2 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
WB 1:500-1:1000  
ELISA 1:25000-1:50000  
IP 0.2-1 μL/mg of lysate  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CNDP2 Antibody (Rabbit Polyclonal antibody) Images
Mouse CNDP2 Immunoprecipitation(IP) 8226

Mouse CNDP2 was immunoprecipitated using:

Lane A:0.5 mg 293T Whole Cell Lysate

0.5 µL anti-Mouse CNDP2 rabbit polyclonal antibody and 15 μl of 50 % Protein G agarose.

Primary antibody:

Anti-Mouse CNDP2 rabbit polyclonal antibody,at 1:1000 dilution

Secondary antibody:

Clean-Blotô IP Detection Reagent (HRP) at 1:1000 dilution

Developed using the DAB staining technique.

Performed under reducing conditions.

Predicted band size: 53 kDa

Observed band size: 53 kDa

Mouse CNDP2 Western blot (WB) 13656

Anti-CNDP2 rabbit polyclonal antibody at 1:500 dilution

Lane A: 293T Whole Cell Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:53 kDa

Observed band size:53 kDa

(We are unsure as to the identity of these extra bands.)

Anti-CNDP2 Antibody Alternative Names
Anti-0610010E05Rik Antibody;Anti-C76600 Antibody;Anti-Cn2 Antibody;Anti-Dip-2 Antibody;Anti-Pep-1 Antibody;Anti-Pep1 Antibody
CNDP2 Background Information

Cytosolic non-specific dipeptidase, also known as CNDP dipeptidase 2, Glutamate carboxypeptidase-like protein 1, Peptidase A, CNDP2 and CN2, is a cytoplasm protein which belongs to the peptidase M20A family. CNDP2 / CPGL is a cytosolic enzyme that can hydrolyze carnosine to yield l-histidine and beta-alanine. CNDP2 / CPGL hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. It may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells. Isoform 1 of CNDP2 / CPGL is ubiquitously expressed with higher levels in kidney and liver (at protein level). Isoform 2 of CNDP2 / CPGL is expressed in fetal tissues, it is only expressed in adult liver and placental tissues. CNDP2 / CPGL is highly expressed in the histaminergic neurons in the tuberomammillary nucleus, implying that it may supply histidine to histaminergic neurons for histamine synthesis.

Full Name
CNDP dipeptidase 2 (metallopeptidase M20 family)
References
  • Bakker,SJ. et al., 2008, Diabetes  57 (12):e16; author reply e17. 
  • Wanic, K. et al., 2008, Diabetes  57 (9): 2547-51.
  • McDonough,CW. et al., 2009, Hum Genet 126 (2): 265-75.
  • Kaur,H. et al., 2009, J Biol Chem. 284 (21):14493-502.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CNDP2 Antibody Rabbit Monoclonal WB,ELISA 50246-R001
    Anti-CNDP2 Antibody Rabbit Polyclonal ELISA 50246-RP01
    Anti-CNDP2 Antibody Rabbit Monoclonal IHC-P 50246-R210
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